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Labaran Waya

Sabon Gano Kanshigar Maganin Ciwon Ciwon Kankara shine Kwayoyin Namu

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A gaban ciwace-ciwacen daji na pancreatic, wasu ƙwayoyin rigakafi suna rushe sunadaran tsarin cikin ƙwayoyin cuta waɗanda ke haifar da ginin nama mai yawa, sanannen shingen jiyya, sabon bincike ya gano. 

Masu bincike daga NYU Grossman School of Medicine sun jagoranta, binciken ya ta'allaka ne akan aikin haɗin gwiwar furotin mai yawa wanda ke tallafawa gabobin kuma yana taimakawa wajen sake gina nama mai lalacewa. Zaɓuɓɓugan furotin na collagen, babban ɓangaren raga, ana ci gaba da rushewa kuma ana maye gurbinsu don kiyaye ƙarfin ɗaure, kuma a matsayin wani ɓangare na aikin warkar da rauni.

Binciken da aka yi a baya ya nuna cewa ƙwayoyin rigakafi da ake kira macrophages suna ba da gudummawa ga tsarin da ake kira desmoplasia, wanda ke haifar da rashin daidaituwa da kuma yawan adadin collagen da ke hana ciwon daji na pancreatic. A cikin wannan mahallin, macrophages kuma an san su don cinyewa da rushe collagen ta hanyar aikin furotin da ake kira mannose receptor (MRC1).

Buga kan layi Afrilu 4 a cikin Ci gaba na National Academys of Sciences, binciken na yanzu ya gano cewa gurɓataccen collagen ya ƙara yawan adadin arginine, amino acid wanda enzyme nitric oxide synthase (iNOS) ke amfani dashi don samar da mahadi da ake kira reactive nitrogen jinsin. (RNS). Wannan, bi da bi, ya haifar da maƙwabta, sel stellate masu tallafi don gina tushen collagen a kusa da ciwace-ciwacen daji, in ji marubutan binciken.

"Sakamakon mu ya nuna yadda ciwace-ciwacen daji na pancreatic ke shirya macrophages don taimakawa wajen gina shingen fibrotic," in ji marubucin binciken farko Madeleine LaRue, PhD. A lokacin binciken, LaRue ya kasance dalibin digiri na biyu a cikin lab na babban marubucin binciken Dafna Bar-Sagi, PhD, S. Farber Farfesa na Biochemistry da Molecular Pharmacology da Mataimakin Dean na Kimiyya a NYU Langone Health. LaRue ya kara da cewa "Za a iya amfani da wannan tsarin kwayoyin don magance sauye-sauyen cutar daji a cikin kyallen jikin da ke kewaye da ciwace-ciwace," in ji LaRue. 

Ciwon daji na pancreatic shi ne na uku da ke haddasa mace-mace masu nasaba da kansa a cikin Amurka, tare da adadin rayuwa na shekaru biyar na 10%. Ciwon daji na pancreatic ya kasance da wahala a magance shi a babban sashi saboda babban hanyar sadarwa na nama na fibrotic a kusa da ciwace-ciwace. Wannan hanyar sadarwar ba wai kawai tana toshe samun dama ta hanyoyin hanyoyin kwantar da hankali ba, har ma tana haɓaka haɓaka mai ƙarfi.

Don binciken na yanzu, gwaje-gwajen sun nuna cewa macrophages da aka girma a cikin jita-jita na abinci mai gina jiki (al'adu), kuma sun canza zuwa yanayin da ke da cutar kansa (M2), sun rushe mafi yawan collagen fiye da macrophages waɗanda ke kai hari kan ƙwayoyin cutar kansa (M1). Bugu da ari, ƙungiyar ta tabbatar da jerin gwaje-gwajen cewa M2 macrophages suna da matakan mafi girma na enzymes waɗanda ke haifar da RNS, irin su iNOS.

Don tabbatar da waɗannan binciken a cikin raye-raye masu rai, ƙungiyar ta dasa ƙwayoyin stelate waɗanda ko dai “an riga an ciyar da su” tare da haɗin gwiwa, ko kuma ana kiyaye su a cikin yanayin da ba a ciyar da su ba, a cikin gefuna na dabbobin binciken tare da ƙwayoyin cutar kansa na pancreatic. Tawagar ta lura da karuwar kashi 100 cikin XNUMX na yawan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.

Mahimmanci, binciken ya nuna a karon farko cewa macrophages kusa da ƙwayoyin kansa na pancreatic, ba wai kawai ɗauka da kuma rushe ƙarin collagen ba a matsayin wani ɓangare na ɓarke ​​​​don sunadaran da ke ciyar da ci gaba mara kyau, amma kuma ana canza su ta hanyar zazzagewa, kamar tsarin sarrafa makamashin su. (metabolism) an sake gyarawa da sigina don gina fibrotic.

Bar-Sagi ya ce "Ƙungiyarmu ta gano wata hanyar da ke haɗa haɗin haɗin gwiwar collagen zuwa ginin yanayi mai juriya a kusa da ciwace-ciwacen daji," in ji Bar-Sagi. "Kamar yadda wannan yanayi mai yawa shine babban dalilin da yasa ciwon daji na pancreatic ke da mutuƙar mutuwa, za a buƙaci ƙarin fahimtar alaƙa tsakanin ɓarkewar furotin da gina shingen kariya don inganta maganin wannan mummunar cutar."

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edita

Edita a shugaba na eTurboNew ita ce Linda Hohnholz. Ta dogara ne a HQ eTN a Honolulu, Hawaii.

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