DISCUSSION
Babban watsawa na SARS-CoV-2 yana faruwa a cikin Chile duk da kamfen ɗin rigakafi mai ƙarfi, wanda galibi ya dogara da rigakafin cutar da ba a kunna ba daga Sinovac Biotech kuma zuwa ɗan ƙaramin allurar rigakafin mRNA daga Pfizer / BioNTech da kuma allurar rigakafin ƙwayoyin cuta daga ƙwayoyin cuta. Oxford/AstraZeneca da Cansino Biologicals.
Cutar sankara ta ƙarshe da aka ruwaito a cikin ƙasar ta sami rinjayen bambance-bambancen SARS-CoV-2 Gamma da Lambda, waɗanda aka ware a matsayin bambance-bambancen damuwa watanni da yawa da suka gabata kuma kwanan nan WHO ta amince da ta a matsayin bambance-bambancen sha'awa. Yayin da bambance-bambancen Gamma ya mallaki maye gurbi 11 a cikin furotin mai karu gami da waɗanda ke cikin yanki mai ɗaure mai karɓa (RBD) da ke da alaƙa da haɓaka ɗaurin ACE2 da kamuwa da cuta (N501Y) ko tserewa na rigakafi (K417T da E484K) furotin mai karu na bambancin Lambda yana da keɓantacce. tsarin maye gurbi na 7 (Δ246-252, G75V, T76I, L452Q, F490S, D614G, T859N) wanda L452Q yayi kama da maye gurbin L452R da aka ruwaito a cikin bambance-bambancen Delta da Epsilon.
An nuna maye gurbin L452R don ba da gudun hijira na rigakafi zuwa ƙwayoyin rigakafi na monoclonal (mAbs) da kuma plasma convalescent.
Haka kuma, an kuma nuna maye gurbin L452R don haɓaka kamuwa da cuta ta hoto ko bidiyo mai zagaya yanar gizo da sauri kuma bayananmu suna ba da shawarar cewa maye gurbin L452Q da ke cikin bambance-bambancen Lambda na iya ba da irin wannan kaddarorin ga waɗanda aka kwatanta don L452R. Abin sha'awa shine, shafewar 246-252 a cikin yankin N-terminal (NTD) na Lambda Spike yana cikin babban wurin antigenic kuma saboda haka, wannan shafewar na iya ba da gudummawa ga tserewa na rigakafi. Haka kuma, maye gurbin F490S shima yana da alaƙa da tserewa zuwa sera.
Daidai da waɗannan abubuwan da suka gabata, sakamakonmu yana nuna cewa furotin mai girma na bambancin Lambda yana ba da tserewa na rigakafi zuwa kawar da ƙwayoyin rigakafi da ke haifar da rigakafin CoronaVac. Ko bambance-bambancen Lambda shima ya tsere zuwa amsawar wayar hannu da aka nuna ta hanyar CoronaVac har yanzu ba a san shi ba.
Mun kuma lura cewa furotin mai karu na bambance-bambancen Lambda ya gabatar da ƙarin kamuwa da cuta idan aka kwatanta da furotin mai karu na bambance-bambancen Alpha da Gamma, dukansu suna da ƙarin kamuwa da cuta.
Tare, bayananmu sun nuna a karon farko cewa maye gurbi a cikin furotin mai karu na nau'in Lambda yana ba da tserewa zuwa kawar da ƙwayoyin rigakafi da haɓaka kamuwa da cuta. Shaidar da aka gabatar anan tana ƙarfafa ra'ayin cewa babban yaƙin neman zaɓe a cikin ƙasashen da ke da hauhawar jini na SARS-CoV-2 dole ne su kasance tare da tsauraran matakan sa ido kan ƙwayoyin cuta da nufin gano sabbin ƙwayoyin cuta da ke ɗauke da maye gurbi da kuma nazarin da ke da niyyar yin nazarin tasirin waɗannan. maye gurbi a cikin tserewa na rigakafi da ci gaban rigakafin rigakafi.
COVID-19 na ci gaba da sauri. Ana iya ganin wannan a Hawaii inda lambobi suka yi ƙasa kuma suka yi tsalle don yin rikodin girma tare da haɓakar yawon shakatawa.
