A cikin wani labarin bita na baya-bayan nan da aka buga a Coordination Chemistry Reviews, ƙungiyar masana kimiyya karkashin jagorancin Farfesa Chang Yeon Lee da Gajendra Gupta na Jami'ar Kasa ta Incheon, Koriya, sun tattauna juyin halitta da ci gaban kwanan nan a fagen MOCs da MOFs na tushen BODIPY, tare da mayar da hankali kan mahallin ' yuwuwar ayyuka a matsayin duka magungunan anticancer da kayan aikin bincike kan kansa. Labarin ya yi bayanin fa'idodi iri-iri da haɗin kai tare da wasu fasahohin likitanci sannan kuma yana magance manyan shingen hanya zuwa aikace-aikacensu.
Don haka, menene waɗannan kayan kuma menene ke sa su haɗuwa mai kyau? MOCs da MOFs ginshiƙan ƙarfe ne waɗanda ke aiki azaman dandamali iri-iri waɗanda za a iya shigar da sabbin ayyuka cikin sauƙi ta hanyar gyare-gyare. Dukansu an yi amfani da su sosai a cikin biomedicine kuma sun nuna yuwuwar a matsayin magungunan anticancer tare da zaɓi mai kyau. Koyaya, lokacin da aka yi amfani da BODIPY a cikin MOCs ko MOFs, kayan aikin hoto na fili na abin da aka haifar na iya zama da kyau a daidaita su don cimma tasiri iri-iri.
Na farko, rukunin tushen BODIPY sune wakilai masu kyau na daukar hoto don maganin photodynamic, a cikin abin da ake kunna magani ta hanyar haske don lalata ƙwayoyin da aka yi niyya. Lokacin da aka haɗa su tare da MOCs ko MOFs, ingancin waɗannan rukunin gidaje kamar yadda magungunan anticancer ke ƙaruwa. Na biyu, rukunin tushen BODIPY suna kula da acidity (pH) na matsakaici. Saboda wasu ciwace-ciwacen ciwace-ciwacen daji suna da ƙarancin pH (acid), waɗannan mahadi za a iya ƙara haɓaka su ta yadda za a yi amfani da wannan tsarin. A ƙarshe, amma tabbas ba kalla ba, ana iya keɓance kaddarorin masu kyalli na MOCs da MOFs ta yadda za a iya gano matsayinsu a cikin sel cikin sauƙi ta hanyar amfani da fasaha mai kyalli. "Sauƙi mai sauƙi na gano magungunan MOC/MOF na BODIPY a cikin kwayoyin cutar kansa da aka yi wa magani zai taimaka wa masanan kwayoyin halitta da tantanin halitta su fahimci hanyoyin aiwatar da waɗannan kwayoyin halitta a kan ciwon daji," in ji Farfesa Lee.
Duk da wasu iyakoki na MOCs/MOFs na tushen BODIPY, kamar haɗaɗɗen cin lokaci da rashin cikakkiyar fahimtarmu game da guba, waɗannan mahadi na iya zama manyan ƴan wasa a cikin yaƙinmu da ciwon daji. "MOCs da MOFs da aka tsara tare da BODIPY suna da duk mahimman abubuwan da ake buƙata don zama ɗan takarar maganin cutar kansa," in ji Farfesa Gupta. Tabbatar cewa kun sanya ido kan waɗannan ci-gaban ƙwayoyin cuta da abubuwan al'ajabi da za su iya kawo wa duniyar maganin cutar kansa da bincike.
ABUBUWAN DA ZA KU GUDU DAGA WANNAN LABARI:
- In a recent review article published in Coordination Chemistry Reviews, a team of scientists led by Professors Chang Yeon Lee and Gajendra Gupta of Incheon National University, Korea, discussed the evolution and recent progress in the field of BODIPY-based MOCs and MOFs, with a focus on the compounds’.
- Despite some of the limitations of BODIPY-based MOCs/MOFs, such as a time-consuming synthesis and our incomplete understanding of its toxicity, these compounds could become key players in our fight against cancer.
- Be sure to keep an eye out for these advanced molecules and the wonders they might bring to the world of cancer therapy and research.
