Labaran Waya

Sabon Magani don Autism da Farfaɗo

Written by edita

Yaran da ke fama da ciwo na Dravet, wani nau'i mai tsanani na farfadiya wanda ke farawa tun suna jariri, suna fuskantar kamawa, yawanci tsawon rayuwarsu. Suna cikin haɗarin mutuwa kwatsam a cikin farfadiya (SUDEP) kuma suna iya haɓaka tawayar hankali da kuma Autism. Magungunan da ake da su yawanci sun kasa inganta waɗannan alamun.

Yanzu, ƙungiyar masana kimiyya a Cibiyar Gladstone ta Lennart Mucke, MD, ta ba da rahoton sabon binciken a cikin mujallar Kimiyya ta Fassarar Medicine wanda zai iya jagorantar ci gaba da ingantattun dabarun warkewa don ciwon Dravet da kuma yanayin da suka shafi.

Masu binciken sun gano a baya, a cikin samfurin linzamin kwamfuta na Dravet Syndrome, cewa ta hanyar cire furotin tau daga dukkan jiki yayin haɓakar tayi yana rage farfadiya, SUDEP, da halaye irin na Autism. A cikin sabon binciken, sun nuna nau'in kwayar halitta mai mahimmanci a cikin kwakwalwa wanda dole ne a rage matakan tau don guje wa waɗannan matsalolin. Sun kuma nuna cewa rage tau yana da tasiri a cikin berayen lokacin da aka jinkirta shiga tsakani har sai bayan haihuwarsu.

"Abubuwan da muka gano suna ba da sabbin fahimta game da hanyoyin salula wanda rage tau ke hana wuce gona da iri a cikin kwakwalwa," in ji Mucke, darektan Cibiyar Gladstone na Cututtukan Jiki. "Suna ƙarfafawa ta fuskar warkewa, tun da a cikin mutane, fara jiyya bayan haihuwa har yanzu yana da yuwuwa fiye da kula da ƴaƴan ciki a ciki."

Tau wata manufa ce ta warkarwa ba kawai don ciwon Dravet ba, har ma da wasu yanayi iri-iri, gami da nau'ikan farfadiya da wasu nau'ikan Autism, da cutar Alzheimer da cututtukan da ke da alaƙa da neurodegenerative.

Nuna Mahimman Kwakwalwa Kwakwalwa

Ƙwaƙwalwar da ke aiki da kyau ya dogara ne akan daidaitattun daidaito tsakanin ayyukan motsa jiki da kuma hanawa neurons-tsohon yana motsa ayyukan wasu kwayoyin halitta, yayin da na karshen ya hana shi. Ciwon Dravet yana haifar da rashin daidaituwa tsakanin waɗannan nau'ikan sel, yana haifar da babban aiki mara nauyi da aiki tare a cikin hanyoyin sadarwar kwakwalwa waɗanda zasu iya bayyana azaman kamawa da sauran alamomi.

Mucke da abokan aikinsa kwanan nan sun nuna cewa cire tau daga dukkan kwakwalwa yana canza ayyukan duka masu motsa jiki da masu hanawa, kodayake ta hanyoyi daban-daban. Binciken na yanzu yana nufin sanin ko yana da mahimmanci don rage tau a cikin ƙwayoyin tsoka ko inhibitory neurons.

Don wannan dalili, masanan kimiyya sun yi amfani da kayan aikin kwayoyin halitta don kawar da tau zaɓaɓɓu daga ɗaya ko wata nau'in tantanin halitta a cikin ƙirar linzamin kwamfuta na Dravet. Sun gano cewa cire tau daga neurons masu ban sha'awa yana rage bayyanar cututtuka, yayin da cire tau daga jijiyoyi masu hanawa bai yi ba.

"Wannan yana nufin cewa samar da tau a cikin neurons masu ban sha'awa ya kafa mataki don duk waɗannan abubuwan da ba su da kyau su faru, ciki har da halayen autistic, farfadiya, da mutuwar kwatsam," in ji Mucke, wanda shi ne Farfesa Joseph B. Martin Distinguished Farfesa na Neuroscience kuma farfesa a fannin ilimin likitanci. Neurology a UC San Francisco.

Fara Jiyya Bayan Haihuwa

Yayin da tsarin kwayoyin halitta da masana kimiyya suka yi amfani da su don cire tau daga takamaiman nau'in tantanin halitta suna da tasiri kuma daidai, har yanzu ba su da sauƙi a yi amfani da su azaman magani ga mutane. Don haka, ƙungiyar ta juya zuwa zaɓi mafi dacewa: rage tau ta duniya a cikin kwakwalwa tare da gutsuttsuran DNA da aka sani da antisense oligonucleotides, ko ASOs. Masanan kimiyya sun ba da maganin anti-tau ASO a cikin kwakwalwar beraye kwanaki 10 bayan haihuwa kuma sun gano cewa yawancin alamun cutar Dravet sun tafi bayan watanni 4.

"Mun lura da raguwar SUDEP mai ƙarfi, ayyukan kamawa, da halaye masu maimaitawa," in ji Eric Shao, PhD, masanin kimiyya a cikin Lab Mucke kuma marubucin farko na binciken.

Bugu da ƙari, maganin ASO ba shi da wani tasiri mai tasiri.

"Muna farin ciki game da waɗannan binciken, musamman tun da wani anti-tau ASO ya riga ya yi gwajin gwaji na Phase I a cikin mutanen da ke fama da cutar Alzheimer," in ji Mucke. "Zai iya zama da amfani a yi la'akari da wannan dabarun kuma don ciwo na Dravet da yanayin da ke da alaƙa. Koyaya, ayyana mafi kyawun lokacin fara jiyya zai zama mahimmanci, saboda taga dama na iya zama kunkuntar. "

Ko da yake cutar Alzheimer, farfadiya, da Autism suna da dalilai daban-daban, duk suna da alama suna da alaƙa da babban rabo mai girma tsakanin ayyukan motsa jiki da inhibitory neuronal-kuma ana iya daidaita wannan rashin lafiyar ta hanyar tau-lowering therapeutics.

Duk da haka, jiyya bisa anti-tau ASOs zai ƙunshi maimaita taps na kashin baya, hanya mafi yawan mutane za su gwammace su guje wa. Sabili da haka, Mucke yana haɗin gwiwa tare da Takeda Pharmaceuticals don haɓaka ƙananan ƙwayoyin cuta waɗanda zasu iya rage matakan tau na kwakwalwa lokacin da ake gudanar da su azaman kwaya.

Shafin Farko

Game da marubucin

edita

Edita a shugaba na eTurboNew ita ce Linda Hohnholz. Ta dogara ne a HQ eTN a Honolulu, Hawaii.

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