Labaran Waya

Sabon Alurar Tushen Suga da ake Ƙirƙira don Melioidosis

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Barazana daga Melioidosis na gaske ne. Kwayar cutar da ke haifar da wannan cuta mai saurin kamuwa da cuta tana jure wa maganin rigakafi, yana sa ganewar asali da magani ya fi rikitarwa kuma yana haifar da adadin mace-mace har zuwa 50%. Farfesa Charles Gauthier na Institut national de la recherche scientifique (INRS) ya shafe shekaru 700,000 da suka gabata yana nazarin cututtukan da aka yi watsi da su. Bayan da yanzu ya sami sama da $ XNUMX a cikin kudade daga Cibiyoyin Binciken Lafiya na Kanada (CIHR), yanzu ya fara gwajin daidaitaccen maganin rigakafi tare da haɗin gwiwar farfesa Éric Déziel da Alain Lamarre.

Burkholderia pseudomallei ana samunsa a cikin laka da ƙasa, galibi a cikin ƙasashen equatorial kamar Australia, Thailand, Indiya, da Brazil. Lokacin da ambaliya ko fari ya faru, yana iya gurɓata barbashi da iska ke ɗauka. "Tare da hauhawar yanayin zafi da haɓakar haɗarin bala'o'i, bincike ya yi hasashen karuwar gurɓatawa da wuraren da ke cikin haɗari. Dole ne mu kasance cikin shiri,” in ji Farfesa Gauthier.

A cikin shekaru biyar masu zuwa, tawagarsa za ta samar da maganin rigakafi na glycoconjugate. Sikari da aka bayyana a saman kwayoyin cutar za a danganta su da wani nau'in furotin da ƙwayoyin T na jiki suka gane su—“sojoji” na rigakafi waɗanda ke haifar da samar da ƙwayoyin cuta. Farfesa Lamarre, wanda ya ƙware a ci gaban rigakafin rigakafi, da Farfesa Déziel, ƙwararre a cikin ƙwayoyin cuta na ƙwayoyin cuta na Burkholderia, za su gudanar da nazarin allurar rigakafi a cikin beraye da kuma bincika yanayin martanin rigakafin.

Kwaikwayi masu ciwon sukari

Tawagar masana kimiyya za su gwada nau'ikan maganin da yawa tare da haɗuwa daban-daban na sarƙoƙin sukari guda uku, ko polysaccharides, wanda ƙwayoyin cuta suka bayyana. Sugars suna da alƙawarin saboda an riga an yi niyya da ƙwayoyin rigakafi. Maimakon ware su kai tsaye daga ƙwayoyin cuta, Farfesa Gauthier yana amfani da kwaikwayi na waɗannan sikari da aka haɓaka a cikin aikinsa na farko. Wannan hanya tana guje wa haɗarin kula da ƙwayoyin cuta.

“Mun sami damar haɗa polysaccharides waɗanda ke yin kwaikwayon na ƙwayoyin cuta, baya ga gane su ta hanyar ƙwayoyin cuta. Aikin majagaba ne,” in ji shi. Koyaya, tsarin haɗin gwiwar zai buƙaci inganta shi don ƙara yawan yawan yawan sukari.

A matsayinsa na memba na cibiyar sadarwa na VALIDATE na Jami'ar Oxford don haɓaka rigakafin rigakafin cututtukan da ba a kula da su ba, Farfesa Gauthier na iya dogaro da taimakon masana kimiyya daga ko'ina cikin duniya. Daya daga cikin wadanda suka hada kai shi ne dan kasar Amurka mai bincike Brad Borlee daga Jami'ar Jihar Colorado, wanda ya ba shi nau'in nau'in Burkholderia pseudomallei. Borlee yana yin sikari waɗanda za a yi amfani da su azaman masu sarrafa sukari “mimics” a cikin binciken rigakafin. Gauthier kuma yana aiki tare da Farfesa Siobhán McClean daga Jami'ar College Dublin, wani mai bincike dan kasar Ireland da ke binciken sunadaran da kwayoyin cutar suka bayyana. Waɗannan sunadaran kuma tsarin garkuwar jiki ya yi niyya kuma ana iya amfani da su tare da sukari don ƙara ingancin maganin.

Shafin Farko

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edita

Edita a shugaba na eTurboNew ita ce Linda Hohnholz. Ta dogara ne a HQ eTN a Honolulu, Hawaii.

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