Sabon Nazari Akan Tasirin Maganin Cutar Zawo Na Cashew Stem Bark Extract

Anacardium occidentale (Ao), itacen cashew na kowa, tsiro ne da aka daɗe ana gane shi a cikin tsarin magungunan gargajiya don yuwuwar warkewarta. Misali, sassa daban-daban na wannan bishiya mai zafi, ganye, haushi, kwaya, da danko, an san suna da maganin zawo. Koyaya, ainihin hanyoyin aiwatar da aiki sun kasance asiri.            

Dokta Kayode E. Adewole daga Jami’ar Kimiyyar Kiwon Lafiya ta Najeriya, da abokan aikinsu sun yi yunkurin ruguza hanyoyin ta hanyar gudanar da bincike kan ayyukan rigakafin cutar gudawa na bishiyar cashew. An buga abubuwan lura da su kwanan nan a cikin Journal of Pharmaceutical Analysis.

Sakamakon abubuwa daban-daban kamar rashin haƙurin abinci, cututtuka na ƙwayoyin cuta, magunguna, da cututtukan hanji, gudawa babban abin damuwa ne ga lafiyar jama'a, kuma yana haifar da mace-mace ga yara. Yawancin lokaci, cutar ta bayyana a matsayin ƙara yawan motsin hanji. Don bincika tsarin rigakafin zawo na cirewar haushi na cashew stem, masu binciken sun mayar da hankali kan hanyoyin salon salula da manyan 'yan wasan kwayoyin da ke cikin motsi mara kyau na gut kuma sun tsara jerin gwaje-gwaje na tushen lab.

Dokta Adewole ya bayyana cewa, “Cutar zawo tana fitowa ne daga ƙaramar aikin tsoka mai santsi na hanji, wanda galibi ana sarrafa ta ta hanyoyin neurophysiological guda uku, dopaminergic, cholinergic, da serotonergic. Don haka, tsarin gwajin mu shine don tada motsin ciki ta hanyar wucin gadi ta kowane ɗayan waɗannan hanyoyin sannan mu ga wanne daga cikinsu ya hana shi ta hanyar tsantsa mai tushe na cashew. An raba gwaje-gwajenmu zuwa kashi biyu, a cikin vivo, ana gudanar da su a cikin raye-raye masu rai, da kuma in vitro, waɗanda aka gudanar akan ƙwayoyin hanji.

Ƙungiyar ta gudanar da magungunan motsa jiki na gastrointestinal, wato metoclopramide (mai karɓar mai karɓa na dopamine), carachol (mai karɓar mai karɓa na acetylcholine), da serotonin (wanda ke motsa masu karɓa na serotonergic), don raba ƙungiyoyin mice. Wasu kungiyoyi guda uku sun sami magunguna iri ɗaya amma an riga an yi musu magani tare da tsantsa mai tushe na cashew.

Sun gano cewa wani yanki na ethyl acetate da aka shirya na tsantsa (mai lakabin AoEF) ya fi muhimmanci ya hana hanyar cholinergic na zubar da ciki da kuma jigilar gastrointestinal amma ba shi da wani tasiri a kan sauran hanyoyi guda biyu, yana ba da kyakkyawar fahimta game da tsarin aikin da aka cire.

A matsayin wani ɓangare na gwaje-gwajen in vitro, masu binciken sun ware ɓangarorin daga hanjin aladun Guinea kuma sun gano cewa a mafi girma maida hankali, AoEF yadda ya kamata da kuma mayar da hankali annashuwa wadannan tube. An ga wannan har ma a cikin sassan da aka riga aka yi wa magani tare da AoEF sannan a bi da su tare da kwayoyin prokinetic kamar histamine, serotonin, da acetylcholine.

Bugu da ari, ta amfani da gas chromatography-mass spectroscopy, ƙungiyar ta gano abubuwan 24 da ke cikin AoEF. Nazarin tushen bioinformatics ya bayyana cewa a cikin waɗannan mahadi, octadecanoic acid 2- (2-hydroxylethoxy) ethyl ester yana da alaƙa mafi girma ga muscarinic acetylcholine receptor M3 (CHRM3). Wannan ya ba ƙungiyar damar tattara shaidu tare daga duk gwaje-gwaje daban-daban kuma su isa ga yanayin da za a iya aiwatar da shi.

Dangane da karfin ilimin gargajiya da kimiyyar zamani, Dokta Adewole da tawagarsa suna fatan ganowar da suka yi zai karfafa samar da sabbin magunguna masu rahusa don magance cutar gudawa.