Loki Therapeutics a yau ya sanar da wallafe-wallafen bincike a cikin jarida, "Magungunan Fassarar Kimiyya", yana nuna yiwuwar AWAKE-LM-TT a cikin maganin ciwon daji na pancreatic. AWAKE-LM-TT, wanda Claudia Gravekamp, โโPh.D., Co-Founder Loki da Associated Farfesa na Microbiology & Immunology a Makarantar Magunguna ta Albert Einstein ya haษaka, yana ba da gudummawa ga rigakafin yara don tetanus don samar da rigakafi mai ฦarfi da kai tsaye. amsa ga m ciwace-ciwacen daji da metastases gabatar da tetanus antigens.
Rubutun mai suna, "Listeria Yana Isar da Protein Tetanus Toxoid zuwa Ciwon Ciwon Ciwon Ciki kuma Yana haifar da Mutuwar Ciwon Ciwon daji a cikin Mice," kuma Dr. Gravekamp, โโPh.D. ya rubuta tare da haษin gwiwa, ya bayyana binciken da ya ฦunshi sabon tsarin kula da ciwon daji na pancreatic wanda Listeria monocytogenes ke zama. ana amfani da shi don isar da sunadaran tetanus toxoid (TT) mai saurin kamuwa da cuta kai tsaye zuwa cikin ฦwayoyin ฦari. Wannan isarwa, Listeria-TT, an nuna shi don haifar da amsawar rigakafi, kunna tetanus toxoid-takamaiman ฦwaฦwalwar ajiyar ฦwayoyin T don kashe ฦwayoyin tumor ductal adenocarcinoma (PDAC) a cikin mice. Lokacin da aka haษe shi da gemcitabine (Listeria-TT + GEM), masu bincike sun lura da raguwar 80% na nauyin ฦwayar ฦwayar cuta ta PDAC da 87% raguwa na metastases tare da karuwar rayuwa ta hanyar 40% idan aka kwatanta da ฦananan ฦwayoyin da ba a kula da su ba, suna ba da shawarar cewa antigens na Listeria-bayar da ฦwaฦwalwar ajiyar zai iya zama. madadin maganin ciwon daji na neoantigen-mai shiga tsakani.
Loki Co-kafa kuma Shugaba Chris Bradley ya ce, โWannan binciken shi ne kawai bakin kankara idan ya zo ga ganowa da kuma gano ingantattun hanyoyin magance cututtukan daji masu wahala. Ciwon daji na pancreatic yana da wuyar ganowa a matakin farko, wanda ke sa neman magani ya fi ฦalubale, tunda galibi ana gano shi a mataki na gaba ko a ฦarshen zamani. Wannan binciken ya nuna gagarumin yuwuwar Loki's AWAKE-LM-TT a matsayin sabon magani don ciwon daji na pancreatic da aka ba shi ikon yin amfani da rigakafin yara don tetanus toxoid don samar da amsa mai ฦarfi da gaggawa nan da nan ga ciwace-ciwacen ciwace-ciwacen ฦwayoyi da metastases waษanda ke gabatar da tetanus antigens. โ
Dr. Gravekamp yayi sharhi, โSaboda wannan bincike, muna da wata sabuwar dabara wacce ba wai kawai za ta iya zama nasara ta immunotherapy wajen magance cutar kansar pancreatic ba, har ma da sauran cututtukan daji. Ciwon daji na pancreatic yana da ฦalubalanci don magancewa a cikin wannan, zuwa tsarin rigakafi, waษannan ciwace-ciwacen ba su bayyana isashen 'baฦi' don jawo hankalin tsarin rigakafi kuma yawanci suna iya hana duk wani martani na rigakafi da ya faru. Hanyarmu da gaske ta sa waษannan ciwace-ciwacen 'sanyi' masu cutarwa su yi zafi sosai don tsarin rigakafi ya kai hari da lalata.
Loki yana shirin shigar da sabon Magani na Bincike (IND) tare da Hukumar Abinci da Magunguna ta Amurka don shirin farko na ษan adam wanda ke binciken AWAKE-LM-TT a cikin maganin ciwon daji na pancreatic. Bayan karษar izinin FDA don IND, Loki yana tsammanin ฦaddamar da gwajin asibiti na Mataki na 1 a cikin rabin na biyu na 2022.