Labaran Waya

Sabon Bincike Akan Maganin Ciwon Kankara

Written by edita

Loki Therapeutics a yau ya sanar da wallafe-wallafen bincike a cikin jarida, "Magungunan Fassarar Kimiyya", yana nuna yiwuwar AWAKE-LM-TT a cikin maganin ciwon daji na pancreatic. AWAKE-LM-TT, wanda Claudia Gravekamp, ​​Ph.D., Co-Founder Loki da Associated Farfesa na Microbiology & Immunology a Makarantar Magunguna ta Albert Einstein ya haɓaka, yana ba da gudummawa ga rigakafin yara don tetanus don samar da rigakafi mai ƙarfi da kai tsaye. amsa ga m ciwace-ciwacen daji da metastases gabatar da tetanus antigens.

Rubutun mai suna, "Listeria Yana Isar da Protein Tetanus Toxoid zuwa Ciwon Ciwon Ciwon Ciki kuma Yana haifar da Mutuwar Ciwon Ciwon daji a cikin Mice," kuma Dr. Gravekamp, ​​Ph.D. ya rubuta tare da haɗin gwiwa, ya bayyana binciken da ya ƙunshi sabon tsarin kula da ciwon daji na pancreatic wanda Listeria monocytogenes ke zama. ana amfani da shi don isar da sunadaran tetanus toxoid (TT) mai saurin kamuwa da cuta kai tsaye zuwa cikin ƙwayoyin ƙari. Wannan isarwa, Listeria-TT, an nuna shi don haifar da amsawar rigakafi, kunna tetanus toxoid-takamaiman ƙwaƙwalwar ajiyar ƙwayoyin T don kashe ƙwayoyin tumor ductal adenocarcinoma (PDAC) a cikin mice. Lokacin da aka haɗe shi da gemcitabine (Listeria-TT + GEM), masu bincike sun lura da raguwar 80% na nauyin ƙwayar ƙwayar cuta ta PDAC da 87% raguwa na metastases tare da karuwar rayuwa ta hanyar 40% idan aka kwatanta da ƙananan ƙwayoyin da ba a kula da su ba, suna ba da shawarar cewa antigens na Listeria-bayar da ƙwaƙwalwar ajiyar zai iya zama. madadin maganin ciwon daji na neoantigen-mai shiga tsakani.

Loki Co-kafa kuma Shugaba Chris Bradley ya ce, “Wannan binciken shi ne kawai bakin kankara idan ya zo ga ganowa da kuma gano ingantattun hanyoyin magance cututtukan daji masu wahala. Ciwon daji na pancreatic yana da wuyar ganowa a matakin farko, wanda ke sa neman magani ya fi ƙalubale, tunda galibi ana gano shi a mataki na gaba ko a ƙarshen zamani. Wannan binciken ya nuna gagarumin yuwuwar Loki's AWAKE-LM-TT a matsayin sabon magani don ciwon daji na pancreatic da aka ba shi ikon yin amfani da rigakafin yara don tetanus toxoid don samar da amsa mai ƙarfi da gaggawa nan da nan ga ciwace-ciwacen ciwace-ciwacen ƙwayoyi da metastases waɗanda ke gabatar da tetanus antigens. ”

Dr. Gravekamp yayi sharhi, “Saboda wannan bincike, muna da wata sabuwar dabara wacce ba wai kawai za ta iya zama nasara ta immunotherapy wajen magance cutar kansar pancreatic ba, har ma da sauran cututtukan daji. Ciwon daji na pancreatic yana da ƙalubalanci don magancewa a cikin wannan, zuwa tsarin rigakafi, waɗannan ciwace-ciwacen ba su bayyana isashen 'baƙi' don jawo hankalin tsarin rigakafi kuma yawanci suna iya hana duk wani martani na rigakafi da ya faru. Hanyarmu da gaske ta sa waɗannan ciwace-ciwacen 'sanyi' masu cutarwa su yi zafi sosai don tsarin rigakafi ya kai hari da lalata.

Loki yana shirin shigar da sabon Magani na Bincike (IND) tare da Hukumar Abinci da Magunguna ta Amurka don shirin farko na ɗan adam wanda ke binciken AWAKE-LM-TT a cikin maganin ciwon daji na pancreatic. Bayan karɓar izinin FDA don IND, Loki yana tsammanin ƙaddamar da gwajin asibiti na Mataki na 1 a cikin rabin na biyu na 2022.

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edita

Edita a shugaba na eTurboNew ita ce Linda Hohnholz. Ta dogara ne a HQ eTN a Honolulu, Hawaii.

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