Indivior PLC yana ba da sanarwar buga bayanan ƙirar ƙirar ƙira yana nazarin hulɗar gasa tsakanin buprenorphine, maganin rashin lafiyar amfani da opioid (OUD), da fentanyl, mai ƙarfi opioid mai ƙarfi, don ƙarin fahimtar yadda buprenorphine zai iya rage ɓacin rai na fentanyl. Binciken mai suna "Modelling buprenorphine rage na fentanyl-induced numfashi ciki" yana samuwa a kan layi kuma zai bayyana a cikin fitowar mai zuwa na JCI Insight, wata jarida da aka yi nazari. Indivior ya goyi bayan binciken.
Wannan pharmacokinetic / pharmacodynamic binciken da nufin yin ƙirar hulɗar buprenorphine da fentanyl a matakin mu-opioid receptor (MOR) akan iskar minti kaɗan a ƙarƙashin haɓakar matakan carbon dioxide a cikin masu sa kai na opioid-naïve da masu amfani da opioid na yau da kullun. Bayanan da aka yi amfani da su don yin samfuri sun fito ne daga binciken likitancin likitancin da aka buga kwanan nan a cikin PLOS ONE. Babban makasudin ƙirar shine don nuna tasirin haɓakar allurai na fentanyl na ciki (0.25-0.70 mg / 70 kg a cikin masu amfani da opioid na yau da kullun) akan ɓacin rai na numfashi idan aka kwatanta da jiko na ciki na ko dai placebo ko buprenorphine wanda ke niyya da adadin plasma a cikin 0.2- 5ng/ml kewayon.
An nuna magungunan Buprenorphine don rashin lafiyar amfani da opioid don rage amfani da opioid mara kyau da kuma mace-mace masu alaka da opioid. Wannan bincike ya bayyana wani tsarin da buprenorphine zai iya rage yawan mutuwar opioid. Bayanan ƙididdiga sun nuna cewa ƙwayar plasma buprenorphine na 2 ng/mL kuma mafi girma na iya samun tasiri mai kariya daga fentanyl-induced damuwa na numfashi a cikin masu amfani da opioid na yau da kullum, tare da rage yiwuwar apnea bayan bayyanar da manyan allurai na fentanyl. Samfurin ya nuna cewa lokacin da zama na MOR ta buprenorphine ya yi girma sosai, fentanyl ba zai iya kunna MOR ba saboda haka ba zai haifar da ƙarin baƙin ciki na numfashi ba a saman tasirin numfashi na buprenorphine a cikin wannan yawan.
"Wadannan bayanan ƙididdiga sun nuna cewa ƙwayar plasma buprenorphine na 2 ng / mL kuma mafi girma suna da alama suna da tasiri mai kariya daga fentanyl-induced damuwa na numfashi," in ji Christian Heidbreder, PhD, Babban Jami'in Kimiyya, Indivior. "Ko da yake an gudanar da binciken tushen a cikin wani wuri mai sarrafawa kuma a cikin ƙananan ƙananan masu amfani da opioid na yau da kullum, ikon buprenorphine don rage haɗarin haɗari mai tsanani na numfashi wanda fentanyl ya haifar da shi ya nuna kuma ya ba da izinin ƙarin bincike a cikin yanayin duniya. ”
ABUBUWAN DA ZA KU GUDU DAGA WANNAN LABARI:
- “Although the source study was conducted in a controlled setting and in a relatively small number of chronic opioid users, the ability of buprenorphine to reduce the risk of serious respiratory events triggered by fentanyl was demonstrated and warrants further investigation in a real-world setting.
- The model shows that when MOR occupancy by buprenorphine is sufficiently high, fentanyl is unable to activate the MOR and consequently will not cause additional respiratory depression on top of the mild respiratory effects of buprenorphine in that population.
- The modeling data indicate that buprenorphine plasma concentrations of 2 ng/mL and higher may have a protective effect against fentanyl-induced respiratory depression in chronic opioid users, with a reduced probability of apnea following exposure to high fentanyl doses.
