Respira Therapeutics, Inc. ya sanar a yau cewa an yi amfani da mai haฦuri na farko a Amurka a cikin gwajin gwaji na multicenter na dan takarar samfurin jagorancinsa, RT234-PAH (vardenafil wanda aka gudanar a matsayin busassun foda mai bushewa). Gwajin VIPAH-PRN 2b (Vardenafil Inhaled for Pulmonary Arterial Hypertension - PRN) zai ฦunshi ฦungiyoyi biyu masu zuwa suna karษar RT234 a matsayin nau'i guda ษaya da aka gudanar ta hanyar Axial Oscillating Sphere bushe foda inhaler. An tsara binciken don kimanta aminci da ingancin farko na RT234 don inganta haษakar alamun episodic da ฦarfin motsa jiki a cikin mutanen da ake bi da su don hauhawar jini na huhu (PAH) tare da ฦungiyar Zuciya ta New York (NYHA) Alamomin Aiki na Class II-III.
"ฦaddamar da wannan gwaji na asibiti yana wakiltar wani muhimmin mataki na Respira kuma mataki ne mai mahimmanci na gaba ga yiwuwar ba marasa lafiya tare da PAH magani mai mahimmanci don sarrafa ฦarancin numfashi, wanda ya hana su yin ayyukan yau da kullum," in ji Carol Satler, PhD. , MD, Shugaba da Babban Jami'in Lafiya na Respira. โMutanen da ke fama da wannan mummunan yanayin da ake fama da su ta hanyar kula da lafiyar jiki har yanzu suna fama da gajeriyar numfashi, gajiya da rashin iya motsa jiki, kuma a halin yanzu babu wasu hanyoyin saurin farawa da ake da su don yin amfani da su kamar yadda ake buฦata don rage ษangarorin. โ
"Ba da damar marasa lafiya na PAH su kasance masu aiki shine mahimmanci ga lafiyar jiki da tunanin su," in ji Raymond L. Benza, MD, Daraktan Sashen Magungunan Cardiovascular a Jami'ar Jihar Ohio Wexner Medical Center. "Yanzu tare da nazarin RT234, muna nazarin ikonmu na haษaka aikin jiki lokacin da majiyyaci ya buฦaci shi. Zai iya zama babban ci gaba a yakin da muke da wannan cuta."
Gwajin VIPAH-PRN 2b (RT234-PAH-CL202) nazari ne na haษaka kashi-kashi don kimanta manyan canje-canje a cikin alamun bayyanar cutar ta RT234 a cikin batutuwa tare da PAH. An yi la'akari da cewa inhaled RT234 (vardenafil inhalation foda) na iya samar da amfanin warkewa don amfani mai yawa a cikin marasa lafiya tare da Hukumar Lafiya ta Duniya (WHO) Rukunin 1 Cutar hawan jini (PH) (Pulmonary Arterial Hypertension [PAH]) don inganta ฦarfin motsa jiki da aiki a ayyukan rayuwar yau da kullun, da kuma rage alamun motsa jiki (misali, dyspnea) da munanan tasirin su akan ingancin rayuwa.
