Labaran Waya

Ganewar mahimmanci da kuma kula da ƙwayoyin cutar kansar ƙwaƙwalwa na yara

Written by edita

Genegoggle yana buɗe kayan chromatin na zahiri (3D DNA folding) na sel waɗanda aka samo daga ɗimbin intrinsic pontine gliomas (DIPG). Aikin na yanzu yana kan hanyar nemo lambobin DNA-DNA waɗanda za a iya amfani da su azaman alamomin nau'in tantanin halitta don siffanta ƙwayoyin DIPG da azaman maƙasudin isar da ƙwayoyi. Michał Marzęcki, Babban Jami'in Fasaha, ya bayyana cewa "wannan wani muhimmin ci gaba ne mai tabbatar da daidaiton mafitarmu da kuma haɓaka ƙimarmu".     

Ɗaya daga cikin alamomin DIPG shine maye gurbi a cikin histone H3.3 wanda ke haifar da canjin amino acid lysine zuwa methionine (K27M), wanda ke rinjayar tsarin epigenetic. Genegoggle ya sami nasarar gano adadin lambobin DNA-DNA (aka DNA madaukai) keɓance ga sel DIPG ɗauke da maye gurbin K27M da canje-canje a cikin bayanin martaba na H3K27me3 idan aka kwatanta da sel na yau da kullun. Ta hanyar amfani da fasahar epigenetic mai yanke-yanke, yawancin waɗannan madaukai na DNA an haɗa su da bambancin bayanin jinsin da bambancin damar chromatin.

"Wadannan sakamakon sun sanar da mu game da bayanan bayanan gyare-gyaren tarihi da yawa don kwatanta jihohin chromatin na sel DIPG mafi kyau, wanda zai ba mu damar gano sababbin halaye da maƙasudin asibiti," in ji Jakub Mieczkowski, PhD, da Babban Jami'in Gudanarwa. An samo bayanan a lokacin haɗin gwiwar Illumina Accelerator da haɗin gwiwar Farfesa Jacek Majewski daga Jami'ar McGill. Lokacin da aka tambaye mu game da makomar Genegoggle, Babban Jami'in Harkokin Kasuwanci Marcin Kruczyk, PhD, ya ce, "mun yi imanin cewa muna da matsayi mai karfi don zagaye na gaba na tara kudade don ciyar da wannan tafiya gaba".

Game da yaɗa intrinsic pontine glioma (DIPG)

Pontine glioma mai yaduwa shine mafi yawan nau'in ciwon daji na kwakwalwar yara. Tsakanin rayuwa ga yara masu DIPG bai wuce shekara ɗaya daga ganewar asali ba, kuma an sami ɗan inganta rayuwa cikin shekaru da yawa. Hanyar ganowa ta yanzu ita ce gwajin MRI (hoton maganadisu na maganadisu) kuma yawanci yana faruwa lokacin da alamun suka ci gaba. Alamar kwayoyin halitta ta DIPG maye gurbi ne a cikin kwayar halittar H3F3A wacce ke rubuto tarihin H3.3.

Game da marubucin

edita

Edita a shugaba na eTurboNew ita ce Linda Hohnholz. Ta dogara ne a HQ eTN a Honolulu, Hawaii.

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