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Mataki ɗaya kusa da sabon maganin Cystic Fibrosis

Written by edita

Entrinsic Bioscience da mai lasisin sa Nuvara Therapeutics sun sanar da cewa mataki ɗaya ne kusa da amfani da tsarin RxAA azaman magani ga marasa lafiya tare da maye gurbin Cystic Fibrosis Class I. Masanin bincike na Jami'ar Florida Dr. Sadasivan Vidyasagar, wanda ya kafa kuma shugaban kwamitin ba da shawara na kimiyya na kamfanin, kwanan nan ya raba wata hanyar da ta dace don maido da asirin anion ta iska a taron Gwajin Biology 2022 da aka gudanar a Philadelphia.      

Vidyasagar da tawagarsa, wadanda suka hada da masu bincike daga UF da Entrinsic Bioscience, sun nuna cewa tsarin Nuvara na VS-009 zai iya zama da amfani ga marasa lafiya tare da Cystic Fibrosis Class I maye gurbi da kuma Class II da III maye gurbi. Za a iya amfani da maganin shi kaɗai ko a haɗe tare da wasu hanyoyin kwantar da hankali don inganta ɓarnar chloride.

Stephen J. Gatto, shugaban zartarwa na Nuvara Therapeutics, ya taya Astrid Grosche da sauran tawagar Dr. Vidyasagar murnar ci gaba da jajircewarsu wajen tuki sabbin hanyoyin da za a tantance aikin epithelial na numfashi.

"Ina so in gode wa Astrid, Dr. Vidyasagar da sauran tawagarsa saboda jajircewar da suka yi don magance maye gurbi na Class I a cikin Cystic Fibrosis, maye gurbi wanda zai iya shafar har zuwa 18% na yawan mutanen CF," in ji Stephen J. Gatto.

Gatto ya ci gaba da cewa: "Wadannan bayanan guda biyu sun nuna cewa yin amfani da tashoshi na ion yana yiwuwa a cikin epithelium na numfashi ta hanyar amfani da abubuwan da suka dace da amino acid," in ji Gatto. “Rashin aikin Ion-channel shine tsakiyar cututtukan da yawa, irin su CF da cututtukan da ke haifar da haɓakar ƙwayoyin mucous, gami da asma da COPD. Waɗannan hanyoyin / magunguna za su ba mu damar daidaita kwararar ions da ruwa zuwa cikin hanyar iska a matakin salon salula tare da ƙarancin illa.

"Har yanzu akwai sauran aiki da za a yi, amma dama tana da ban sha'awa da gaske kuma tana iya wakiltar ci gaba a cikin kula da cututtukan cututtukan zuciya da cututtukan da ke da alaƙa," in ji Gatto.

Vidyasagar ya kuma gabatar da fosta akan kayan aikin lab ɗinsa ya haɓaka don mafi kyawun auna peristalsis na hanji da hulɗar matsa lamba na intraluminal, ƙwayar tsoka, da canje-canje a cikin ƙarar ruwa.

"Wadannan bayanan guda biyu suna da mahimmanci a cikin cewa suna nuna ikon yin gyaran gyare-gyaren sunadaran epithelial transmembrane proteins (eTMPs) tare da zaɓi na amino SAA (RxAAs)," in ji Dokta William Denman, Babban Mashawarcin Likita ga Nuvara Therapeutics. "Wannan yana buɗe kofa don ingantaccen magani mara guba a matakin salon salula, ba tare da la'akari da ilimin etiology ba."

Dokta Denman ya ci gaba da cewa, “A yanzu ana iya ƙaddara jiyya na gaba kuma a keɓance su don kowane tashoshi da cuta - magani na musamman na gaskiya. Ana buƙatar ƙarin aiki, amma wannan na iya ba da damar madadin magani a matakin salon salula a tsakanin nau'ikan cututtuka tare da ƙarancin illa."

Entrinsic Bioscience shine farkon UF wanda ke cikin UF Innovate | Hanzarta a Sid Martin Biotech a Alahua. Kamfanin yana bunkasa dukkan halittun na glucose, glucose na glucose don ruwan hoda, kiwon lafiya da kuma lafiyarsu, rashin lafiyan fata, da kulawar fata.

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edita

Edita a shugaba na eTurboNew ita ce Linda Hohnholz. Ta dogara ne a HQ eTN a Honolulu, Hawaii.

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