Maganin Majagaba Na Cututtuka Masu Korar Mafi Yawan Cutar da ɗan adam

Kamfanin Majagaba na Flagship a yau ya ƙaddamar da Vesalius Therapeutics, wani kamfani da ya mayar da hankali kan sake fasalin fahimta da kuma maganin cututtukan da ke haifar da kashi 90% na cututtukan ɗan adam. Tuta ta fara ƙaddamar da dala miliyan 75 don tallafawa haɓaka dandamali na Vesalius da bututun farko na sabbin magunguna. Christopher Austin, MD, wanda a baya ya yi aiki a matsayin darektan kafa Cibiyar Ci gaban Kimiyyar Fassara ta Kasa (NCATS) a Cibiyar Kiwon Lafiya ta Kasa (NIH), zai jagoranci kamfanin a matsayin Shugaba. Dokta Austin ya shiga Flagship a cikin Maris na 2021 a matsayin Shugaba- Abokin Hulɗa.               

“Ci gaban da aka samu wajen magance wasu cututtukan da ke damun al’umma bai yi sauri ba saboda masana’antar mu ba ta fayyace matsalar yadda ya kamata. A Flagship, mun fahimci cewa don magance waɗannan yanayi muna buƙatar yin tunani daban, "in ji Doug Cole, MD, Manajan Abokin Hulɗa a Flagship Pioneering, wanda ya kafa Vesalius, kuma Shugaban Hukumar Gudanarwa. "An kafa Vesalius don daidaita ainihin yadda muke kallo, ganowa, da kuma kula da cututtuka na yau da kullun waɗanda fasahar kere-kere ta yi watsi da su. Mun yi imanin tsarin da muka yi zai yi tasiri ga ikonmu na magance cututtukan da ke haifar da kashi casa'in na wahala da mutuwa a duniya."

A halin yanzu, yawancin cututtuka da ke shafar miliyoyin marasa lafiya a duk duniya suna da ganewar asali guda ɗaya (misali, ciwon sukari) wanda ya ƙunshi cututtuka daban-daban, kowanne yana shafar ƙungiyoyin marasa lafiya da ke da dalilai na ilimin halitta. Wannan sau da yawa yana haifar da alamomi na musamman, waɗanda ke haifar da rashin daidaituwa a cikin da'irori na kwayoyin halitta wanda ya bambanta da direbobi da aka samu a cikin sauran kungiyoyi - ma'ana cewa marasa lafiya waɗanda a yau suna raba ganewar asali, a gaskiya, ba duka suna fama da cutar ba.

Dandalin Vesalius' DIAMOND yana aiki kamar prism wanda ke raba marasa lafiya zuwa ƙungiyoyi masu ma'ana ta hanyar amfani da hankali na wucin gadi da koyan na'ura don kawo haske ga ilimin halitta wanda ke ƙarƙashin gabatarwar asibiti. DIAMOND yana ƙirƙira tsarin gwaji na majinyaci wanda yake amfani da shi don tantancewa da kuma fayyace ƴan takarar magunguna don maido da waɗannan da'irori zuwa kyakkyawan aiki. Wannan hanyar za ta bayyana sabbin hanyoyin haɓaka hanyoyin warkewa don cututtukan da ba a iya kamuwa da su a baya.

Dokta Austin ya yi tsokaci, “cututtukan da ba su da yawa ba su kaɗai ba ne, a haƙiƙa ƙungiyar taurari ce ta nau’ukan cututtuka daban-daban na jinsi da na halitta waɗanda ke shafar marasa lafiya daban-daban. Dandalin mu na DIAMOND yana ba mu damar fayyace waɗannan ƙayyadaddun ƙungiyoyin majiyyata kuma mu fahimci ilimin halittun da suka raba su zuwa gida a kan ingantacciyar hanyar warkewa ga ƙungiyar marasa lafiya da ta dace. Ta hanyar karkatar da ƙungiyoyin majiyyata ta alamomin alamominsu, kwayoyin halitta, da ilmin halitta, mun yi imanin za mu iya inganta damar samun nasarar samar da magunguna don kamuwa da cututtuka. Bugu da kari, ta hanyar yin amfani da samfuran gwaji na tushen sel na ɗan adam, dandalinmu yana da matuƙar inganci wajen gwada sabbin zaɓuɓɓukan warkewa don inganta rayuwar marasa lafiya a ƙarshe."

"Muna buƙatar manyan ra'ayoyi da buri masu ƙarfin gaske idan har a ƙarshe za mu samar da mafita masu tasiri ga wasu cututtukan da ke da nauyi a cikin al'umma, kuma kwarewar Chris sama da shekaru kusan goma a matsayin darektan Cibiyar Ci gaban Kimiyyar Fassara ta Ƙasa a NIH daidai yake. wanda ya dace da manufar Vesalius, "in ji Noubar Afeyan, Ph.D., Wanda ya kafa kuma Shugaba na Flagship Pioneering. “Maganganun dabarunsa ya haifar da ci gaba a kimiyyar fassara wanda ya haɓaka haɓaka da yawa na magungunan canza canji. Har ila yau yana da kwarewa mai zurfi a cikin binciken kwayoyin halitta ta hanyar aikinsa tare da Cibiyar Nazarin Halittar Halittar Dan Adam da kuma a Merck wanda shine mafi dacewa ga kalubale na gaba na kiwon lafiya. " 

Vesalius ya sami ci gaba mai mahimmanci wajen gano da'irorin kwayoyin halitta a cikin ƙananan jama'a na marasa lafiya a cikin cututtuka da yawa masu wuyar magancewa, yana ba da hujjar ra'ayi don tsarinsa, da kuma buɗe kofa ga nau'o'in jiyya daban-daban. Kamfanin na sa ran daukar mutane fiye da 200 a cikin shekaru biyu masu zuwa don tallafawa ci gaban dandamali da shirye-shiryensa.