Maganin alopecia yana ceton 80% na gashi

A KYAUTA Kyauta 7 | eTurboNews | eTN
Avatar na Linda Hohnholz
Written by Linda Hohnholz

Manya da mai tsanani alopecia areata (AA) wanda ya dauki OLUMIANT® (baricitinib) ya sami babban gashin kai, gashin ido da gashin gira kuma kusan 75% na waɗanda suka amsa ga OLUMIANT 4-mg sun sami 90% ɗaukar hoto a cikin makonni 52, Eli Lilly da Kamfanin da Incyte sun sanar a yau. a Cibiyar Nazarin Kankara ta Amurka (AAD) Taron Shekara-shekara. A cikin Fabrairu 2022, Hukumar Abinci da Magunguna ta Amurka (FDA) ta ba da fifikon bita ga OLUMIANT a cikin AA mai tsanani a matsayin yuwuwar maganin cututtukan farko. Lilly tana tsammanin yanke hukunci a cikin Amurka, Tarayyar Turai da Japan a cikin 2022.

A cikin ƙididdigar mako-mako 52 da aka tattara, marasa lafiya a asali suna da ma'ana Mai tsananin Kayan Alopecia (SALT) maki na 85.5 (85.5% hasarar gashin kai, ko kuma kashi 14.5% rufe gashin kai); An bayyana AA mai tsanani da samun makin SALT ≥50 (≥50% asarar gashi). A asali, 69.4% da 57.9% suna da babban gashin gira da asarar gashin ido, bi da bi, kamar yadda aka bayyana sakamakon Clinician-Reported (ClinRO) maki ≥2. Matsakaicin shekarun marasa lafiya ya kasance shekaru 37.6, tare da asarar gashi yana farawa kusan shekaru 25 da ma'anar shekaru 12.2 tun farkon bayyanar cututtuka.

Daga cikin marasa lafiya waɗanda suka ɗauki OLUMIANT 4-mg, biyu daga cikin biyar (39.0%, n=201/515) sun sami babban girman gashin kai, wanda aka ayyana azaman ƙimar SALT ≤20, ko 80% ko fiye da rufe gashin kai, kuma kusan uku daga waje. na hudu daga cikin waɗancan marasa lafiya (74.1%, n = 149/201) kuma sun sami ƙimar SALT ≤10, ko 90% ɗaukar gashi, a cikin makonni 52. Na dabam, fiye da biyu daga cikin marasa lafiya biyar tare da ƙimar asali na ClinRO ≥2 ( gira: 44.1%, n = 154/349; gashin ido: 45.3%, n = 139 / 307) sun ga cikakken girma ko girma tare da ƙananan gibba a gira da gashin ido. gashi.

Daga cikin marasa lafiya waɗanda suka ɗauki OLUMIANT 2-mg, fiye da ɗaya cikin biyar (22.6%, n = 77/340) sun sami babban girman gashin kai kuma biyu daga cikin uku na waɗannan marasa lafiya (67.5%, n = 52/77) sun sami 90 % ko fiye da rufe gashi a makonni 52. Na dabam, fiye da ɗaya cikin biyar da ɗaya a cikin marasa lafiya huɗu, bi da bi ( gira: 22.9%, n = 55/240; gashin ido: 25.5%, n = 51/200), ya ga cikakken girma ko sake girma tare da ƙarancin giɓa a gira da gashin ido. gashi.

Waɗannan ƙididdigar makwanni 52 da aka tattara sun nuna ci gaba da haɓakawa a fatar kai, gira da gashin gashin ido daga sakamakon makonni 36 da aka buga a yau a cikin New England Journal of Medicine kuma an gabatar da su a 2021 European Academy of Dermatology and Venereology (EADV) Congress.

“Ko mutanen da ke da alopecia areata suna fama da asarar duk gashin da ke jikinsu ko tabo da bacewar gira ko gashin ido, wannan cutar ta autoimmune na iya yin muni. Cutar tana shafar mutane masu shekaru daban-daban, ”in ji Brett King, MD, Ph.D., FAAD, mataimakin farfesa a fannin ilimin fata a Makarantar Magungunan Yale kuma jagorar marubucin waɗannan nazarin. "A cikin 2022, OLUMIANT na iya zama magani na farko da aka taɓa yarda da shi don kula da manya tare da alopecia areata. Yana da ban mamaki cewa kusan kashi 40% na marasa lafiya akan OLUMIANT 4-mg, waɗanda dukkansu sun fara da aƙalla 50% asarar gashin kai, sun sami cikakkiyar murfin gashin kai ko kusan cikar gashin kai, kuma an sami irin wannan cigaba a tsakanin waɗancan majinyata masu mahimmancin gira ko gashin ido. shiga.”

A cikin kimantawa na OLUMIANT 4-mg da 2-mg na aminci na dogon lokaci, yawan adadin abubuwan da aka ruwaito akai-akai akai-akai har zuwa makonni 52 (matsakaicin 56 makonni bayyanarwa) sun kasance daidai da mako 36, lokacin sarrafa wuribo kuma sun haɗa da babban numfashi. kamuwa da cuta, ciwon kai, kuraje, kamuwa da cuta na urinary fili da karuwa a alamomin jini masu alaƙa da tsoka. Babu sabbin sigina na aminci.

“Bayanan inganci na OLUMIANT na dogon lokaci sun bayyana gagarumin sake girma na fatar kan mutum, gashin ido da gashin gira kuma muna jin daɗin abin da sakamakon zai iya nufi ga marasa lafiya. Bayanan lafiyar mu na alopecia areata yana ƙara ƙarin shaida ga ɗayan mafi girma da kuma mafi tsawo na bayanan aminci a cikin aji mai hanawa na JAK, ciki har da shekaru tara da shekaru 19,000 masu haƙuri a cikin shirinmu, "in ji Lotus Mallbris, MD, Ph.D., mataimakin shugaban kasa. na ci gaban rigakafi na duniya da harkokin kiwon lafiya a Lilly. "Muna farin ciki OLUMIANT na iya zama yuwuwar maganin cutar farko da aka amince da ita a wannan shekara ga manya masu fama da alopecia areata."

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Avatar na Linda Hohnholz

Linda Hohnholz

Edita a shugaba don eTurboNews bisa ga eTN HQ.

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