Labaran Waya

Ciwon Jini na Yaro: Muhimman Matsayin Nama

Written by edita

Tushen ginin kwayoyin halitta na yawancin sunadaran dabbobi, amino acid valine, yana taka muhimmiyar rawa a ci gaban ciwon daji da ake gani a cikin ƙwayar cutar sankarar ƙwayar cuta ta T cell, sabon bincike ya nuna.

Masu bincike a NYU Langone Health, da Sashen Nazarin Pathology, da Laura da Isaac Perlmutter Cibiyar Cancer, binciken ya nuna cewa kwayoyin halittar da ke amfani da valine a cikin sel sun fi aiki a cikin kwayoyin T masu ciwon daji fiye da kwayoyin T.                                                                                                       

Toshe wadannan kwayoyin halittar da ke da alaka da valine ba wai kawai ya haifar da raguwar valine a cikin kwayoyin cutar sankarar bargo ba, har ma ya hana wadannan kwayoyin cutar daga girma a cikin dakin gwaje-gwaje. Kashi 2 cikin ɗari na ƙwayoyin T masu ciwon daji ne kawai suka rayu.

Bugu da ari, gwaje-gwajen sun nuna cewa canje-canje (maye gurbi) a cikin lambar DNA na kwayar halittar NOTCH1, wanda aka fi gani a cikin marasa lafiya da ke fama da cutar sankarar bargo, yana ƙarfafa ci gaban ciwon daji ta hanyar ƙara yawan matakan valine.

An buga a mujallar Nature online a ranar 22 ga watan Disamba, binciken ya hada da gwaje-gwajen da aka yi a cikin kwayoyin cutar sankarar dan Adam da aka girma a cikin dakin gwaje-gwaje da kuma dasa su a cikin berayen da suka kamu da wannan ciwon daji, wanda ya samo asali ne daga fararen jini a cikin kasusuwa.

Karin gwaje-gwajen sun nuna cewa ciyar da berayen leukemic abinci maras-valine na tsawon makonni uku ya katse ci gaban ƙari. Har ila yau, abincin ya rage yawowar ƙwayoyin kansar jini da aƙalla rabi kuma a wasu lokuta zuwa matakan da ba a iya ganewa. Sabanin haka, sake shigar da valine zuwa abinci ya haifar da ci gaban ciwon daji.

WTM London 2022 Za a gudanar da shi daga 7-9 Nuwamba 2022. Yi rijista yanzu!

"Binciken mu ya tabbatar da cewa T cell m lymphoblastic cutar sankarar bargo ya dogara sosai kan wadatar valine kuma rashi na valine na iya dakatar da ci gaban wannan ciwon daji," in ji mai binciken co-jagorancin Palaniraja Thandapani, PhD, abokin karatun digiri a NYU Grossman School of Medicine da kuma Cibiyar Cancer ta Perlmutter.

Tawagar masu binciken na da tsare-tsare a shekara mai zuwa don gwada ko rage cin abinci mai arzikin valine, kamar nama, kifi, da wake, magani ne mai inganci ga masu fama da cutar kansa. Ana samun abinci mai ƙarancin valine cikin sauƙi, in ji Thandapani, kamar yadda aka riga aka yi amfani da su don magance rashin daidaituwar acid a cikin jiki da ke da alaƙa da cututtukan ƙwayoyin cuta waɗanda ke shafar metabolism na hanji.

Babban mai binciken Iannis Aifantis, PhD, ya ce ƙila ƙirar gwajin za ta iya haɗa maganin rage cin abinci tare da venetoclax, maganin da aka riga aka amince da shi don amfani a Amurka don yawancin sauran nau'in cutar sankarar bargo.

Haɗin ƙwayoyi yana da mahimmanci, in ji shi, saboda irin waɗannan ƙuntatawa na abinci ba zai yiwu ba a cikin dogon lokaci. Wannan ya faru ne saboda sanannen yuwuwar ɓatawar tsoka da lalacewar kwakwalwa daga rashi na valine mai tsawo.

"Hanyoyin mu na asibiti za su ƙunshi amfani da abinci maras-valine don rage yawan adadin ƙwayoyin T masu fama da cutar sankarar lymphoblastic zuwa matakin da ya yi ƙasa da yadda kwayoyi za su iya hana ci gaban ciwon daji yadda ya kamata," in ji Aifantis, Farfesa Hermann M. Biggs kuma shugaban kungiyar. Sashen Ilimin Halitta a NYU Grossman da Perlmutter.

Aifantis ya ce yawancin tubalan ginin tantanin halitta, da suka haɗa da sunadaran, nucleotides, da fatty acid, ana buƙatar don ciwon daji ya girma da yaduwa. Aƙalla rabin dozin sauran amino acid, musamman maɗaukakin lysine, sun shiga cikin cututtukan daji, amma ba a san takamaiman matsayinsu ba. Ya yi gargadin cewa an gwada dabarun abinci kawai don magance cutar kansa shekaru da yawa tare da ƙarancin shaidar kimiyya na kowane fa'ida. Ya ce ana buƙatar ƙarin bincike, gami da shirin gwajin asibiti na ƙungiyar, kafin a ba da shawarar duk wani ƙa'idodin magani.

Ƙungiyar Ciwon daji ta Amirka ta kiyasta cewa fiye da Amirkawa 1,500, yawancin yara, suna mutuwa kowace shekara daga cutar sankarar bargo ta lymphoblastic T cell. Wani 5,000 kuma za a sake kamuwa da cutar. Wannan nau'in ciwon daji ya kai kusan kashi ɗaya bisa huɗu na duk cutar sankarar bargo.

Tallafin kuɗi don binciken an bayar da tallafin ne daga Cibiyoyin Kiwon Lafiya na Ƙasa P30CA016087, P01 CA229086 da R01 CA228135; Cutar sankarar bargo & Lymphoma Society; Shirin NYSTEM na Ma'aikatar Lafiya ta Jihar New York; da Ƙungiyar Cibiyar Nazarin Ciwon daji ta Amirka Incyte Corporation Cibiyar Nazarin Ciwon daji ta Ciwon daji.

Aifantis mai ba da shawara ne na Foresite Labs, kamfanin saka hannun jari na kiwon lafiya da ke San Francisco wanda ke da buƙatun kuɗi don haɓaka hanyoyin kwantar da cutar sankarar bargo. Binciken haɗin gwiwar binciken Aristotelis Tsirigos, PhD, yana aiki a matsayin mai ba da shawara na kimiyya ga Intelligencia.AI a birnin New York, wani kamfani na software wanda ke amfani da na'ura don bunkasa magungunan ciwon daji. Ana gudanar da sharuɗɗan waɗannan shirye-shiryen daidai da manufofin NYU Langone.

Bayan Thandapani, Aifantis da Tsirigos, sauran masu binciken NYU Langone da ke cikin binciken sune masu binciken haɗin gwiwar binciken Andreas Kloetgen; Matiyu Witkowski; da Christina Glytsou; da kuma nazarin masu binciken haɗin gwiwar Anna Lee; Eric Wang, Jingjing Wang; Sarah LeBoeuf; Kleopatra Avrampou; da Thales Papagiannakopulos.

Shafin Farko

Game da marubucin

edita

Edita a shugaba na eTurboNew ita ce Linda Hohnholz. Ta dogara ne a HQ eTN a Honolulu, Hawaii.

Labarai
Sanarwa na
bako
1 Comment
sabon
tsofaffin Yawancin Kashe
Bayanin Cikin Lissafi
Duba duk maganganu
nasara murna

Ina shaidawa yadda Dr Ogbeifun ke warkar da ciwon daji na da tushensa & Ganye, Ganyensa sun tabbata 100% WhatsApp him +2348106087837 gmail. [email kariya] godiya

1
0
Za a son tunanin ku, don Allah sharhi.x
()
x
Share zuwa...