Takardar binciken kwanan nan [1], mai taken "Yawancin Cutar Cutar Cutar Hepatitis B a cikin Amurka" da aka buga a watan Yuni 2020, ta nuna kiyasin gabaɗayan kamuwa da kamuwa da cutar hanta ta B (HBV) a cikin Amurka na marasa lafiya miliyan 1.59 (kewayo). 1.25-2.49 miliyan). Dukkan Hukumar Lafiya ta Duniya (WHO) da Ma'aikatar Lafiya da Sabis na Jama'a ta Amurka (DHHS) sun fito da tsare-tsaren kawar da cutar hanta.
Nazarin ASC22 Phase IIb (ClinicalTrials.gov Identifier: NCT04465890) wani bazuwar, makafi guda ɗaya, mai sarrafa wuribo, gwajin asibiti da yawa a cikin Sin wanda ke kimanta inganci da amincin marasa lafiya na 149 CHB don maganin 24-mako na 1 mg / kg ko 2.5 mg/kg ASC22 ko madaidaicin placebo da ake bayarwa sau ɗaya kowane mako biyu (Q2W) tare da NAs. Sakamakon wucin gadi, wanda aka karɓa don gabatarwar baki a cikin Late Breaking Session a Hanta Meeting® 2021 ta Ƙungiyar Amirka don Nazarin Cututtukan Hanta (AASLD) ta nuna cewa a cikin marasa lafiya tare da matakin antigen na Hepatitis B (HBsAg) matakin ≤ 500 IU. / mL, kusan 19% (3/16) na marasa lafiya a cikin rukunin jiyya sun sami asarar HBsAg ba tare da wani batun da aka samu asarar HBsAg a cikin rukunin placebo ba kuma babu sake dawowa bayan kashi na ƙarshe na ASC22, yana nuna maganin aikin HBV.
Mataki na IIa da IIb nazarin asibiti na ASC22 don maganin aikin HBV an zaɓi su don haɗawa a cikin "Mafi kyawun Takaitaccen Takaitaccen Taron Hanta" a cikin 2021 ta kwamitin nazarin AASLD. Irin wannan haɗawa shine girmamawa guda ɗaya kuma yana nuna babban matakin wanda kwamitin nazarin AASLD ya kula da binciken Ascletis a cikin maganin aikin CHB.
Ascletis ya sanar da cewa ya sami lasisi na duniya da keɓaɓɓen kamar na 8 Nuwamba, 2021 daga Suzhou Alphamab don haɓakawa da kasuwanci ASC22 don duk cututtukan ƙwayar cuta ciki har da Hepatitis B. Littattafan Ascletis tallace-tallace a duniya don ASC22 na duk cututtukan hoto.
ASC22 shine mafi ci gaba na matakin rigakafi na asibiti a duniya don maganin aikin CHB, watau asarar HBsAg, ta hanyar toshe hanyar PD-1/PD-L1.
ABUBUWAN DA ZA KU GUDU DAGA WANNAN LABARI:
- Sakamako na wucin gadi, wanda aka karɓa don gabatarwar baki a cikin Late Breaking Session a Hanta Meeting® 2021 ta Ƙungiyar Amirka don Nazarin Cutar Hanta (AASLD) ta nuna cewa a cikin marasa lafiya tare da matakin antigen na Hepatitis B (HBsAg) matakin ≤ 500 IU. / mL, kusan 19% (3/16) na marasa lafiya a cikin rukunin jiyya sun sami asarar HBsAg ba tare da wani batun da aka samu asarar HBsAg a cikin rukunin placebo ba kuma babu sake dawowa bayan kashi na ƙarshe na ASC22, yana nuna maganin aikin HBV.
- NCT04465890) bazuwar, makafi guda ɗaya, mai sarrafa wuribo, gwaji na asibiti da yawa a cikin Sin wanda ke kimanta inganci da amincin marasa lafiya na 149 CHB don maganin 24-mako na 1 mg / kg ko 2.
- Ascletis ya sanar da cewa ya sami lasisi na duniya kuma na keɓance tun daga ranar 8 ga Nuwamba, 2021 daga Suzhou Alphamab don haɓakawa da tallata ASC22 don duk cututtukan hoto da suka haɗa da Hepatitis B.
