Alamar Cutar Hanta mai Fatty, Biopsy Hanta, da Cirrhosis a Yara

Sabbin bayanan gaskiya na duniya da ke kimanta alanine aminotransferase (ALT) a cikin yara sun gano bambance-bambance a cikin yaduwa da tsananin cutar hanta mai ƙiba (NAFLD). Binciken, Bambanci a cikin Alanine Aminotransferase a cikin Yara tare da Ciwon Hanta mara Barasa, an buga shi a cikin mujallar yara da aka sake dubawa. An fitar da bayanan daga ƙungiyar TARGET-NASH mai ci gaba, wanda jagoran shaida na ainihi Target RWE ya dauki nauyinsa.

NAFLD ya ci gaba da zama ɗaya daga cikin cututtuka na yau da kullum na yau da kullum, wanda ya shafi yara a cikin shekaru biyu, kuma ana ci gaba da karuwa. a tsakanin jinsi da kabilanci / kabilanci subgroups.1,2 Yawan NAFLD ya karu sosai tare da karuwar yawan kiba a cikin yara.3

Wannan sabon binciken yana bayyana rarraba halayen asibiti da na rayuwa tsakanin yaran da suka yi rajista a cikin babban ƙungiyar bayanan duniya ta ainihi TARGET-NASH. Masu bincike sun ƙaddamar da rarraba matakan ALT kololuwa da kuma rarraba halayen asibiti ta tarihin biopsy da matakin matakin ALT mafi girma (≤70,>70 zuwa ≤250, da> 250 U / L) don gano cututtuka da tsarin jiyya. a cikin wannan girma, amma rashin karatu yawan.

Binciken ya haɗa da yara 660 masu tsaka-tsakin shekaru 13. Abubuwan da aka gano sun haɗa da:

• Jimlar yara 187 da aka yi wa biopsy, sun fi zama Hispanic ko Latino (67% vs. 57%) da kuma samun cirrhosis (10% vs. 1%).

Yawan cutar cirrhosis ko kowane matakin fibrosis na hanta ya fi yawa a tsakanin yara masu matsakaicin ALT> 70 U/L.

Yawan ciwon sukari na Nau'in 2 ya kasance sau 2.2 a tsakanin yara masu ALT>250 U/L idan aka kwatanta da yara masu matsakaicin ALT tsakanin 71 zuwa 250 da yara masu girma ALT ≤ 70 U/L.

Eduardo Castillo-Leon, MD, Ma'aikatar Ilimin Yara da Yara, Makarantar Magunguna, Jami'ar Emory ya ce "Akwai abin mamaki mai yawan adadin marasa lafiya na yara tare da kololuwar ALT fiye da 250 a cikin wannan ƙungiyar ta gaske ta duniya." "Nazarin da suka gabata na nazarin NAFLD na yara ya faru ne musamman a cikin gwaje-gwaje masu sarrafawa tare da ƙayyadaddun ƙayyadaddun haɗawa / keɓancewa da rashin iya kallon ci gaban lokaci a cikin yawan jama'a na duniya. Sharuɗɗan haɗaɗɗiya da yawa don wannan binciken sun ba da damar nazarin waɗancan marasa lafiya tare da dabi'u na yau da kullun zuwa matsakaicin matsayi na ALT, yawan jama'ar da galibi ba a kula da su."

"Mafi girma matakan ALT sun haɗu da haɓakar haɓakar cututtuka da kuma matakan ci gaba na NAFLD, musamman a tsakanin 'ya'yan Hispanic," in ji Miriam Vos, MD, MSPH, Ma'aikatar Ilimin Ilimin Yara, Makarantar Magunguna, Jami'ar Emory, da likita a Kiwon Lafiyar Yara na Yara. Atlanta. "Wadannan binciken sun goyi bayan ƙarin buƙatun hanyoyin warkewa da ƙima mai tsanani a cikin yara masu manyan matakan ALT."

Binciken ya haɗa da yaran da suka yi rajista tsakanin Agusta 1, 2016, da Oktoba 12th, 2020, tare da aƙalla ma'aunin ALT ɗaya bayan rajista.

TARGET-NASH ƙungiya ce mai lura da tsayin daka ta duniya ta manya da mahalarta yara tare da NAFLD da/ko NASH suna samun kulawa ta yau da kullun daga cibiyoyin ilimi da al'umma a Amurka da Turai, suna yin rajista sama da mahalarta 7,000 har zuwa yau.