A cewar ADx Health, "Abin mamaki, mutane suna raba kashi 99% na ka'idar jinsi ɗaya. 1% na musamman ya haɗa da canje-canje zuwa takamaiman sansanonin nucleotide, wanda ke haifar da canje-canje ga takamaiman kwayoyin halitta, kuma a wasu lokuta, canje-canjen haɗari ga wasu cututtuka,” gami da haɗarin cutar Alzheimer.
Yanzu an yarda da cewa cutar Alzheimer ta haifar da duka abubuwan da za a iya canzawa (kamar abinci mai gina jiki, motsa jiki, barci) da kuma abubuwan da ba za a iya canzawa ba (genetics, shekaru, jima'i) abubuwan haɗari. Yayin da APOE shine mafi yawan sanannun kwayoyin halitta da ke hade da hadarin cutar Alzheimer, gwajin polygenic na GenoRisk yana kimanta kwayoyin 29 ban da APOE.
Duk da haka, yawancin binciken bincike a baya sun yi amfani da haɗarin kwayoyin halitta na APOE kawai wajen tantance batutuwa, suna barin gagarumin gibi a fahimtar cikakken hoton haɗarin haɗari ga AD, wanda shine dalilin da ya sa ADx Health ya kirkiro sabuwar hanyar gwada Alzheimer tare da gwajin GenoRisk.
Bayanan binciken GenoRisk ya nuna cewa za'a iya samun haɗari mai yawa a cikin nau'in APOE da aka ba. A wasu lokuta, mutanen da ke da bambance-bambancen APOE mai ƙananan haɗari na iya kasancewa suna da haɗarin kwayoyin halitta gaba ɗaya fiye da wanda ke da bambance-bambancen APOE mafi girma sakamakon haɗar shekaru da daidaita jima'i.
"Tare da fahimtar yadda yawancin kwayoyin halitta ke hulɗa da juna wajen tsinkayar hadarin AD, irin wannan nau'in kima na polygenic zai iya ba da ƙarin haske game da yadda ake gudanar da Alzheimer na mutum, ciki har da yadda ake kula da marasa lafiya, ƙarshen gwajin gwaji, da matakan rage haɗari", in ji Ryan Fortna. , MD, daya daga cikin marubutan binciken.
