Sabon Bincike Yayi Bayanin Dalilin da yasa COVID-19 Ke haifar da Asarar Kamshi

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Avatar na Linda Hohnholz
Written by Linda Hohnholz

An buga shi a kan layi a ranar 2 ga Fabrairu a cikin mujallar Cell, sabon binciken ya gano cewa kamuwa da cuta tare da ƙwayar cuta, SARS-CoV-2, a kaikaice yana saukar da aikin masu karɓar olfactory (OR), sunadaran a saman ƙwayoyin jijiya a cikin hanci waɗanda ke ganowa. kwayoyin da ke hade da wari. 

Masu bincike daga NYU Grossman School of Medicine da Jami'ar Columbia suka jagoranta, sabon binciken na iya ba da haske game da tasirin COVID-19 akan sauran nau'ikan ƙwayoyin kwakwalwa, da kuma sauran cututtukan da ke daɗe da cutar COVID-19 kamar "hazo na kwakwalwa," ciwon kai, da damuwa.

Gwaje-gwaje sun nuna cewa kasancewar kwayar cutar a kusa da ƙwayoyin jijiya (neurons) a cikin nama mai kamshi ya haifar da kumburin ƙwayoyin rigakafi, microglia da ƙwayoyin T, wannan ma'ana da hana kamuwa da cuta. Irin waɗannan ƙwayoyin suna fitar da sunadaran da ake kira cytokines waɗanda suka canza aikin kwayoyin halitta na ƙwayoyin jijiya masu ƙanshi, ko da yake kwayar cutar ba za ta iya cutar da su ba, in ji marubutan binciken. Inda ayyukan ƙwayoyin rigakafi za su rabu da sauri a cikin wasu al'amuran, a cikin kwakwalwa, bisa ga ka'idar ƙungiyar, siginar rigakafi ya ci gaba a hanyar da za ta rage ayyukan kwayoyin da ake bukata don gina masu karɓa na olfactory.

Canji a Architecture

Alama ta musamman na kamuwa da cutar COVID-19 ita ce asarar wari ba tare da cushewar hanci da aka gani tare da wasu cututtuka kamar mura na gama gari ba, in ji masu bincike. A mafi yawan lokuta, asarar warin yana ɗaukar makonni kaɗan kawai, amma sama da kashi 12 cikin ɗari na marasa lafiya na COVID-19, rashin aikin wari yana ci gaba da kasancewa ta hanyar ci gaba da raguwar ikon yin wari (hyposmia) ko canje-canjen yadda mutum ya fahimci wari guda (parosmia).

Don samun haske game da asarar wari da COVID-19 ya haifar, marubutan na yanzu sun binciki sakamakon kwayoyin cutar SARS-CoV-2 a cikin hamsters na zinare da kuma cikin nama mai kamshi da aka ɗauka daga gawar mutum 23. Hamsters suna wakiltar kyakkyawan tsari, kasancewar dabbobi masu shayarwa waɗanda duka sun dogara da jin wari fiye da mutane, kuma waɗanda suka fi kamuwa da kamuwa da kogon hanci.

Sakamakon binciken ya ginu kan ganowa tsawon shekaru da yawa cewa tsarin da ke juya kwayoyin halitta ya ƙunshi hadaddun alaƙar 3-D, inda sassan DNA suka zama mafi ko žasa da damar yin amfani da na'urar karanta kwayoyin halittar tantanin halitta bisa mahimman sigina, kuma inda wasu sarƙoƙi na DNA suka yi madauki. a kusa don samar da hulɗar dogon zango wanda ke ba da damar daidaita karatun kwayoyin halitta. Wasu kwayoyin halitta suna aiki a cikin "kwakwalwa" na chromatin - rukunin sunadaran gina jiki waɗanda ke ɗauke da kwayoyin halitta - waɗanda suke buɗewa kuma suna aiki, yayin da wasu kuma aka haɗa su kuma an rufe su, a matsayin wani ɓangare na "ginin makaman nukiliya."

A cikin binciken na yanzu, gwaje-gwajen sun tabbatar da cewa kamuwa da cuta ta SARS-CoV-2, da kuma rigakafin rigakafi zuwa gare ta, yana rage ikon sarƙoƙi na DNA a cikin chromosomes waɗanda ke yin tasiri ga ginin ginin mai karɓar ƙamshi don buɗewa da aiki, da madauki don kunnawa. maganganun kwayoyin halitta. A cikin hamster da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta gano ƙungiyar binciken ta gano ci gaba da raguwa mai yawa na ginin mai karɓa na olfactory. Sauran ayyukan da waɗannan marubutan suka buga suna ba da shawarar cewa an haɗa ƙwayoyin jijiyoyi zuwa cikin yankuna masu hankali, kuma cewa ci gaba da halayen ƙwayoyin cuta a cikin kogon hanci na iya yin tasiri ga motsin rai, da ikon yin tunani a sarari (fahimi), daidai da dogon COVID.

Gwaje-gwajen da aka yi a cikin hamsters da aka yi rikodin tsawon lokaci sun nuna cewa rage ka'idodin masu karɓar neuron na ƙamshi ya ci gaba bayan canje-canje na ɗan lokaci wanda zai iya shafar ma'anar wari ta warke ta zahiri. Marubutan sun ce wannan yana nuna cewa COVID-19 yana haifar da rugujewa mai dorewa a cikin ka'idojin chromosomal na maganganun kwayoyin halitta, wakiltar wani nau'i na "ƙwaƙwalwar nukiliya" wanda zai iya hana maido da OR kwafin ko da bayan an share SARS-CoV-2.

A mataki na gaba, ƙungiyar tana duban ko kula da hamsters tare da dogon COVID tare da steroids na iya hana lalata halayen rigakafi (ƙumburi) don kare gine-ginen nukiliya. 

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Avatar na Linda Hohnholz

Linda Hohnholz

Edita a shugaba don eTurboNews bisa ga eTN HQ.

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