Sabuwar Zabin Nunawa ga Marasa lafiya a Babban Haɗari don Ciwon daji na Pancreatic

Cibiyar Kiwon Lafiya ta Jami'ar Hackensack ta ƙaddamar da sabon shirin sa ido wanda ke duba mutanen da ke cikin haɗarin kamuwa da ciwon daji na pancreatic.             

Gwajin IMMray® PanCan-d shine gwajin jini na farko akan kasuwa wanda aka keɓe don gano farkon familial ko na gadon pancreatic ductal adenocarcinoma (PDAC).

Marasa lafiya waɗanda suka cancanci za su sami duka gwajin hoto da kuma gwajin biomarker na zamani wanda ke auna martanin tsarin rigakafi ga cutar pancreatic a cikin jini.

"An gano ciwon daji na farko, mafi kyawun damar samun nasarar magani," in ji Rosario Ligresti, MD, shugaban Gastroenterology a Cibiyar Kiwon Lafiya ta Jami'ar Hackensack, Cibiyar Kwarewa ta Kasa ta Pancreas tun daga 2013, inda aka ba da wannan sabon shirin a matsayin wani ɓangare na babban shirin sa ido na babban haɗari na asibiti don ciwon daji na pancreatic.

Abin takaici, binciken ya nuna kusan kashi ɗaya bisa huɗu na mutanen da suka cancanci yin sa ido kan haɗari a zahiri suna amfani da shi, amma Dokta Ligresti ya yi imanin cewa wannan sabon gwajin jini zai zama mai canza wasa.

"Canwon daji na pancreatic, daya daga cikin mafi munin ciwon daji, yana da wuyar ganewa da wuri, a wani mataki lokacin da aikin tiyata, kawai maganin warkewa, zai yiwu," Dr. Ligresti ya bayyana. "An nuna wannan sabon gwajin don gano ciwon daji na pancreatic a matakin farko a cikin marasa lafiya masu haɗari, tare da burin kama shi kafin ya sami damar yaduwa zuwa sauran kyallen takarda."

Wanene ake ganin yana da babban haɗari? 

Ciwon daji na pancreatic na iya gudana a cikin iyali da/ko ana iya haɗa shi da yanayin kwayoyin halitta wanda ke ƙara haɗarin wasu nau'in ciwon daji. Ana kiran wannan ciwon daji na pancreatic na iyali kuma ya haɗa da yanayi a cikin 'yan'uwa, iyaye da kakanni ta cikin tsararraki na dangin ku. Kai da iyalinka na iya kasancewa cikin haɗari idan 2 ko fiye da dangi na digiri na farko ko aƙalla membobin iyali 3 an gano su da ciwon daji na pancreatic.

Menene ma'aunin kulawa na yanzu don dubawa?

A halin yanzu, ana yin gwajin ƙwayar ƙwayar cuta don ciwon daji ta amfani da MRI ko endoscopic duban dan tayi (EUS). Wannan gwaji ne na musamman wanda ya ƙunshi endoscope da duban dan tayi mai tsayi don yin hoton ƙwayar ƙwayar cuta daidai. Ana yin gwaje-gwajen kowace shekara kuma duka biyun suna da fa'ida da rashin amfani. MRI na iya zama mai wahala, tsada da cin lokaci. EUS ya ƙunshi ɗan ƙaramin ƙwanƙwasa endoscopy kuma yana buƙatar azumi da kwantar da hankali. Cibiyar Kiwon Lafiya ta Jami'ar Hackensack tana yin gwajin ƙwayar cuta ta wannan salon tsawon shekaru da yawa. Kafin yanzu, ba a sami takamaiman gwajin jini na musamman ko na kasuwanci don ba da izinin gwajin cutar kansar ƙwayar cuta ba.

Wanene ya cancanci wannan sabon sa ido kan ciwon daji na pancreas?

Yin gwajin kansar hanji yana da mahimmanci a cikin ƙungiyoyi masu haɗari masu zuwa. Duk wani mara lafiya da ya girmi shekaru 18 tare da:

• maye gurbin BRCA

• Cystic Fibrosis

• Familial Adenomatous Polyposis (FAP)

• Familial Atypical Multiple Melanoma (FAMMM)

• Ciwon Kankara Na Gadon Nonpolyposis Colorectal (HNPCC) ko Lynch Syndrome

• Ciwon daji na gado

• maye gurbin PALB2

• Cutar Peutz-Jeghers

• Tarihin iyali na ciwon daji na pancreas a cikin dangi biyu na farko

Menene ka'idar tantancewa?

Marasa lafiya za su sami cikakkiyar shawara tare da Dr. Ligresti. Sannan za a yi gwajin IMMray PanCan-d da MRI ko EUS da aka yi. Da zarar an sami dukkan sakamakon, za su gana da Dr. Ligresti don duba su da kuma shirin ci gaba da sa ido. Ana yin wannan a kowace shekara.

Me yasa gano ciwon daji na pancreatic da wuri yana da mahimmanci? Alamun cututtuka yawanci suna tasowa ne kawai tare da cututtukan ƙarshen zamani, don haka yawancin ciwon daji na pancreatic ana gano su a ƙarshen matakai lokacin da jiyya ba su da tasiri.

Wanene ke cikin haɗarin kamuwa da ciwon daji na pancreatic? Gano majiyyatan da ke cikin haɗarin haɓaka cutar saboda sanannun maye gurbi ko tarihin iyali na ciwon daji na pancreatic na iya zama mahimmanci don gano ta da wuri. Ƙungiyoyin ƙananan haɗari suna wakiltar wani kaso mai tsoka na duk lokuta na ciwon daji na pancreas.

Ta yaya wannan sabon gwajin ke aiki? IMMray PanCan-d yana nazarin ma'aunin halitta 9 a cikin jini don gano pancreatic ductal adenocarcinoma (PDAC), mafi yawan nau'in ciwon daji na pancreatic. Alamar halittu da ke cikin matakai masu yawa na salon salula ciki har da metabolism, kumburi da lalacewar nama / gyare-gyare, tare da CA19-9, an haɗa su a cikin binciken. Ana auna martanin samfurin ga kowane mai alamar halitta sannan a haɗa ta amfani da algorithm don tantance sakamakon gwaji na “Gabatar Sa hannun Haɗari Mai Girma”, “Maɗaukaki don Sa hannun Babban Haɗari”, ko “Borderline”.

Ayyukan Gwaji: A cikin littafin da Brand et al ya buga kwanan nan a Clinical and Translational Gastroenterology, gwajin IMMray PanCan-d ya nuna ji na 92% da takamaiman 99% a cikin gano adenocarcinoma pancreatic pancreatic (PDAC) ta amfani da serum. Gwajin IMMray PanCan-d ya sami damar gano Stage I & II PDAC tare da hankali 89% da takamaiman 99%.