Sabon Nazari Akan Tsabtace Tsabtace Jijiyoyin Ku

A KYAUTA Kyauta 8 | eTurboNews | eTN
Avatar na Linda Hohnholz
Written by Linda Hohnholz

Farfado da tsarin da ke raguwa yayin da muke tsufa na iya kare kariya daga atherosclerosis, babban dalilin bugun zuciya da bugun jini. A cikin binciken da aka buga a kan layi a yau a cikin Ci gaba na Cibiyar Nazarin Kimiyya ta Kasa (PNAS), masana kimiyya a Kwalejin Kimiyya na Albert Einstein karkashin jagorancin Ana Maria Cuervo, MD, Ph.D., sun yi nasarar rage ƙananan ƙwayar jijiya a cikin berayen da ba za su haɓaka ba. raunuka. Masu binciken sun yi haka ne ta hanyar haɓaka autophagy na chaperone-mediated autophagy (CMA), tsarin kula da gidan salula wanda Dr. 

"Mun nuna a cikin wannan binciken cewa muna buƙatar CMA don kare kariya daga atherosclerosis, wanda ya zama mai tsanani kuma yana ci gaba lokacin da CMA ya ƙi-wani abu wanda kuma ya faru lokacin da mutane suka tsufa," in ji Dokta Cuervo, farfesa na ci gaba da ilimin kwayoyin halitta da kuma magani. , Shugaban Robert da Renée Belfer don Nazarin Cututtukan Neurodegenerative, da kuma babban darektan Cibiyar Nazarin tsufa a Einstein. "Amma daidai yake da mahimmanci, mun tabbatar da cewa haɓaka ayyukan CMA na iya zama ingantacciyar dabara don magance atherosclerosis da dakatar da ci gabanta."

CMA mai ban sha'awa

CMA tana kiyaye sel suna aiki akai-akai ta hanyar zaɓen ƙasƙantar da yawancin sunadaran da sel suka ƙunshi. A cikin CMA, sunadaran "chaperone" na musamman suna ɗaure da sunadaran a cikin cytoplasm kuma suna jagorantar su zuwa tsarin salula mai cike da enzyme wanda ake kira lysosomes don narkewa da sake yin fa'ida. Dokta Cuervo ya ƙaddamar da yawancin 'yan wasan kwayoyin da ke cikin CMA kuma ya nuna cewa CMA, ta hanyar lalatawar sunadaran sunadaran lokaci, yana tsara tsarin tafiyar da kwayoyin halitta da yawa ciki har da glucose da lipid metabolism, circadian rhythms da DNA gyara. Ta kuma gano cewa rushewar CMA yana ba da damar sunadaran da suka lalace su taru zuwa matakan masu guba, suna ba da gudummawa ga tsufa da kuma lokacin da haɓaka mai guba ke faruwa a cikin ƙwayoyin jijiya - zuwa cututtukan neurodegenerative ciki har da Parkinson, Alzheimer's, da cutar Huntington.

An gane nasarorin Dr. Cuervo a cikin 2019 lokacin da aka zabe ta zuwa Cibiyar Nazarin Kimiyya ta Kasa (NAS). A cikin 1996, NAS ta fara gayyatar sabbin membobinta da aka zaɓa don ƙaddamar da wani labarin Inaugural na musamman ga PNAS wanda zai jaddada gudummawar kimiyyar memba. Sakamakon jinkirin da ke da alaƙa da cutar ta COVID-19, takarda ta yau kan rawar kariya ta CMA akan atherosclerosis ita ce takardar PNAS ta farko ta Dr.

Yaki da Baya ga Plaque

Cutar cututtukan zuciya (CVD) ita ce babbar hanyar mutuwa a duniya, tare da fiye da 80% na wadanda CVD ke mutuwa saboda bugun zuciya da bugun jini. CVD, bi da bi, yawanci ana danganta shi da atherosclerosis: ginin plaque (wani abu mai ɗaki wanda ya ƙunshi mai, cholesterol, calcium, da sauran abubuwa) a cikin ganuwar arteries. Tara plaque yana taurare da kunkuntar arteries, yana hana su isar da jini mai iskar oxygen zuwa tsokar zuciya (wanda ke haifar da bugun zuciya), kwakwalwa ( shanyewar jiki), da sauran sassan jiki.

Don bincika rawar CMA a cikin atherosclerosis, Dokta Cuervo da abokan aiki sun inganta atherosclerosis a cikin mice ta hanyar ciyar da su abinci mai kitse na Yammacin Turai na tsawon makonni 12 da kuma kula da ayyukan CMA a cikin abubuwan da suka shafi aortas na dabbobi. Ayyukan CMA da farko sun karu don amsa kalubalen abinci; Bayan makonni 12, duk da haka, ginin plaque yana da mahimmanci, kuma kusan babu ayyukan CRMA a cikin sel guda biyu masu santsi - wanda ke haifar da gurbata plaque a cikin arteies.

"CMA ya zama kamar yana da matukar muhimmanci wajen kare macrophages da santsin ƙwayoyin tsoka - yana taimaka musu suyi aiki akai-akai duk da cin abinci na pro-atherosclerotic-aƙalla na ɗan lokaci, har sai aikin CMA ɗin su ya ƙare," in ji Dokta Cuervo. Ta lura cewa ciyar da abinci mai kitse ga ɓeraye gabaɗaya baya cikin ayyukan CMA ya haifar da ma fi ƙarfin shaida na mahimmancin CMA: plaques kusan 40% ya fi girma fiye da waɗanda ke cikin dabbobin da suma ke kan abinci mai mai yawa.

Na Mice da Haka Maza

Masu binciken sun sami shaidar cewa raunin CMA yana da alaƙa da atherosclerosis a cikin mutane kuma. Wasu marasa lafiya da suka yi shanyewar jiki suna yin aikin tiyata, wanda aka sani da carotid endarterectomy, wanda ke cire sassan da suka shafi plaque na arteries na carotid don rage haɗarin bugun jini na biyu. Dr. Cuervo da abokan aikinta sunyi nazarin ayyukan CMA a cikin sassan carotid artery daga 62 marasa lafiya na farko da suka biyo bayan shekaru uku bayan tiyata.

"Wadancan marasa lafiya da ke da matakan CMA mafi girma bayan bugun jini na farko ba su taba samun na biyu ba, yayin da bugun jini na biyu ya faru a kusan dukkanin marasa lafiya da ƙananan aikin CMA," in ji Dokta Cuervo. "Wannan yana nuna cewa matakin aikin CMA ɗin ku bayan endarterectomy zai iya taimakawa wajen tsinkayar haɗarin ku don bugun jini na biyu da kuma jagorantar jiyya, musamman ga mutanen da ke da ƙananan CMA."

Juya CMA, Tunatar da Atherosclerosis

Binciken shine farkon wanda ya nuna cewa juyawa CMA zai iya zama hanya mai mahimmanci don hana atherosclerosis daga zama mai tsanani ko ci gaba. Masu binciken sun haɓaka CMA a cikin ƙwayoyin ƙwayoyin cuta waɗanda aka ciyar da pro-atherosclerotic, abinci mai kitse na Yammacin Turai kuma daga baya aka kwatanta su da mice masu sarrafa abinci iri ɗaya don makonni 12. Berayen da suka haɓaka CMA sun inganta bayanan lipid na jini sosai, tare da raguwar matakan cholesterol sosai idan aka kwatanta da mice masu sarrafa. Raunin da ya samu a cikin berayen da aka canza ta kwayoyin halitta sun kasance mafi ƙanƙanta kuma mafi ƙanƙanta cikin tsanani idan aka kwatanta da plaques a cikin mice masu sarrafa su. Abin farin ciki, mutane ba za su buƙaci canjin kwayoyin halitta don amfana daga wannan binciken ba.

"Ni da abokan aiki na mun haɓaka magungunan ƙwayoyi waɗanda suka nuna alƙawari don aminci da haɓaka ayyukan CMA a cikin mafi yawan ƙwayoyin linzamin kwamfuta da kuma a cikin kwayoyin da aka samo asali," in ji Dokta Cuervo. Einstein ya shigar da kayan fasaha akan wannan fasaha mai tushe.

Takardar PNAS tana da taken "Tallafin kariya na autophagy mai tsaka-tsakin tsaka-tsaki a kan atherosclerosis." Sauran marubutan Einstein sune Julio Madrigal-Matute, Ph.D., Dario F. Riascos-Bernal, Antonio Diaz, MD, Ph.D., Inmaculada Tasset, Ph.D., Adrian Martin-Segura, Ph.D., Susmita Kaushik, Ph.D., Simoni Tiano, MD, Matthieu Bourdenx, Ph.D., Gregory J. Krause, MS, Nicholas Sibinga, MD, Fernando Macian, MD, Ph.D., da Rajat Singh, MD sauran takardar. Marubuciya mai haɗin gwiwa ita ce Judith C. Sluimer, Ph.D., na Cibiyar Kiwon Lafiya ta Jami'ar Maastricht a Netherlands da Jami'ar Edinburgh a Burtaniya.

Game da marubucin

Avatar na Linda Hohnholz

Linda Hohnholz

Edita a shugaba don eTurboNews bisa ga eTN HQ.

Labarai
Sanarwa na
bako
0 comments
Bayanin Cikin Lissafi
Duba duk maganganu
0
Za a son tunanin ku, don Allah sharhi.x
()
x
Share zuwa...