Nasarar Gwajin Nasarar Asibiti Don Magance Mummunan Shanyewar Kwakwalwa Ta Amfani da Jinin Cibin Mutum

An gudanar da nazarin mataki na farko a kan marasa lafiya masu shekaru 45-80 wadanda suka ci gaba da ciwon bugun jini mai tsanani. An samo jinin igiyar ciki daga lissafin jini na jama'a na StemCyte dangane da nau'in jini na ABO/Rh, wasan Antigen na Human Leukocyte Antigen (HLA) na> 4/6, da adadin tantanin halitta na jimlar cell mononuclear (MNC) na 0.5-5 x 107 Kwayoyin / kg. Bugu da ƙari, allurai huɗu (4) 100 ml na mannitol an yi su ta cikin jijiya mintuna 30 bayan dashen jinin cibiya da kowane sa'o'i 4 bayan haka.

Sakamako na farko shine adadin marasa lafiya waɗanda suka haɓaka grafts tare da cututtukan gida (GVHD) a cikin kwanaki 100 bayan ƙarin jini. Sakamako na biyu sune canje-canje a cikin Ƙirar Lafiya ta Ƙasa (NIHSS), Barthel index, da Berg Balance Scale. A cikin wani yanayi, mai haƙuri mai shekaru 46 mai shekaru tare da tarihin hauhawar jini da hemodialysis don cututtukan renal na ƙarshen zamani an bi da su ta hanyar amfani da hUCB tare da ABO/Rh iri ɗaya, wasan 6/6 HLA, da ƙididdigar MNC na 2.63 x 108. sel/kg. Mai haƙuri bai gabatar da mummunan abubuwan da suka faru ba ko GVHD a lokacin binciken 12-watanni. Makinsa na NIHSS ya ragu daga 9 zuwa 1; Sakamakon Scale Berg Balance ya karu daga 0 zuwa 48, kuma ƙimar Barthel ya karu daga 0 zuwa 90. Wannan binciken na farko ya nuna cewa mai haƙuri mai haƙuri tare da hemiplegia saboda bugun jini na ischemic ya warke gaba daya a cikin watanni 12 bayan samun allogeneic UCB far.

"Mun yi matukar farin ciki da nasarar da aka samu na binciken asibiti na StemCyte's Phase I," in ji StemCyte Shugaba da Shugaba Jonas Wang, PhD. "Tare da mummunan bugun jini shine na biyu da na uku babban dalilin mutuwa da nakasa, bi da bi, a duk duniya, wannan sakamakon ya yi fice kamar yadda ba zato ba tsammani." Kusan 30% -35% na mutanen da ke fama da bugun jini suna mutuwa kuma kusan kashi 75% na waɗanda suka tsira suna samun nakasa ta dindindin. Jiyya na yanzu a cikin m lokaci sun hada da yin amfani da thrombolytic, anticoagulant, da kuma antiplatelet jamiái. Duk da haka, yin amfani da irin waɗannan abubuwa yana ƙara yawan zubar jini da 15% -20%.

Kwayoyin da ke haifar da jini na igiya suna yaduwa zuwa ƙwayoyin jijiyoyi, kuma an gano su suna da tasiri wajen magance cututtuka masu yawa na neurodegenerative. A cikin bugun jini na kwakwalwa, allurar ciki ta UCB da MNCs na iya dawo da damar motsa jiki da kuma samar da tasirin neuroprotective kamar yadda aka nuna ta hanyar rage yawan bayyanar cututtuka irin su TNF-alpha, IL-1β da IL-2.

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Shafin Farko