Sabuwar Tafarki Zuwa Gaggawar Cutar COVID-19 Wanda Aka Yi A Cikin Zinare

Yaduwar COVID-19 cikin sauri, cutar da kwayar cutar SARS-CoV-2 ta haifar, ta haifar da matsalar lafiyar jama'a a duniya. Gano farkon COVID-19 da keɓewa shine mabuɗin don sarrafa yaduwar cuta da kuma kare mutane masu rauni. Matsakaicin halin yanzu don gano cutar COVID-19 shine juyar da transcriptase-polymerase chain reaction (RT-PCR), dabarar da ake gano kwayoyin halittar kwayar cutar bayan sun juye juye-juye na haɓakawa. Koyaya, wannan dabarar tana ɗaukar lokaci, ƙirƙirar bayanan gwaji a cikin cibiyoyin bincike kuma yana haifar da jinkirin kamuwa da cuta.      

A cikin wani binciken kwanan nan da aka buga a cikin Biosensors da Bioelectronics, masu bincike daga Koriya da China sun gabatar da wani sabon salo na tushen fasahar nanotechnology wanda zai iya rage lokacin da ake buƙata don gano cutar ta COVID-19. Su surface-ingantaccen Raman watsawa (SERS) -PCR gano dandali-shirya ta amfani da zinariya nanoparticles (AuNPs) a cikin cavities na Au 'nanodimple' substrates (AuNDSs) - iya gano hoto ko bidiyo mai zagaya yanar gizo da sauri genes bayan kawai 8 hawan keke na amplification. Wannan shine kusan kashi ɗaya bisa uku na adadin da ake buƙata tare da RT-PCR na al'ada.

RT-PCR na al'ada ya dogara ne akan gano siginar kyalli, don haka ana buƙatar awanni 3-4 don gano SARS-CoV-2. Wannan gudun bai isa ba idan aka yi la'akari da yadda saurin COVID-19 ke yaɗuwa. Mun so nemo hanyar da za mu yanke wannan lokacin akalla da rabi,” in ji Farfesa Jaebum Choo, yana bayyana dalilin da ya sa binciken. An yi sa'a, amsar ba ta yi nisa ba. A cikin wani binciken da aka buga a baya a cikin 2021, ƙungiyar Farfesa Choo ta ƙera wani dandalin gano sabon labari wanda AuNPs ke samar da siginonin SERS masu girma da yawa waɗanda aka tsara su a cikin ramukan AuNDS ta hanyar fasaha mai suna DNA hybridization. Dangane da wannan binciken da aka yi a baya, Farfesa Choo da tawagarsa sun haɓaka sabon dandalin SERS-PCR don gano cutar COVID-19.

Sabuwar binciken SERS-PCR da aka haɓaka yana amfani da siginar SERS don gano “gada DNA”—ƙananan binciken DNA waɗanda sannu a hankali ke rushewa a gaban ƙwayoyin ƙwayoyin cuta da aka yi niyya. Sabili da haka, a cikin samfurori daga marasa lafiya masu inganci don COVID-19, ƙaddamarwar DNA gada (sabili da haka siginar SERS) yana ci gaba da raguwa tare da ci gaba na hawan PCR. Sabanin haka, lokacin da SARS-CoV-2 ba ya nan, siginar SERS ba ya canzawa.

Ƙungiyar ta gwada tasirin tsarin su ta amfani da alamun wakilai biyu na SARS-CoV-2, wato, furotin ambulan (E) da RNA-dependent RNA polymerase (RdRp) genes na SARS-CoV-2. Yayin da ake buƙatar hawan hawan keke 25 don gano tushen tushen RT-PCR, dandalin SERS-PCR na tushen AuNDS yana buƙatar hawan keke 8 kawai, yana rage tsawon lokacin gwaji. "Ko da yake sakamakonmu na farko ne, sun ba da muhimmiyar hujja-na-ra'ayi don ingancin SERS-PCR a matsayin fasaha na bincike. Dabarar SERS-PCR na tushen AuNDS sabuwar dandamali ce mai ban sha'awa wacce za ta iya rage lokacin da ake buƙata don gano kwayoyin halitta idan aka kwatanta da dabarun RT-PCR na al'ada. Wannan ƙirar za a iya ƙara faɗaɗawa ta hanyar haɗa na'urar samfur ta atomatik don haɓaka tsarin binciken kwayoyin halitta na gaba, "in ji Farfesa Choo.

Tabbas, SERS-PCR na iya zama muhimmin kayan aiki a cikin arsenal ɗin mu game da cutar ta COVID-19. Hakanan zai iya haifar da sauyi a fagen bincike na ƙwayoyin cuta, yana canza yadda muke gano cututtuka da kuma magance cututtukan nan gaba.

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Shafin Farko