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Psoriasis na Al'aura: Sakamako na Sabon Nazari

Amgen a yau ya sanar da sakamako mai kyau na saman layi daga gwajin DISCREET, wani lokaci na 3, multicenter, randomized, placebo-controlled, nazarin makafi biyu don tantance ingancin Otezla® (apremilast) a cikin manya tare da matsakaici zuwa matsananciyar psoriasis da matsakaici zuwa matsakaici. mai tsanani plaque psoriasis.

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A binciken ya nuna cewa baka Otezla 30 MG kullum sau biyu cimma wani asibiti da ma'ana da kuma ilimin kididdiga gagarumin ci gaba, idan aka kwatanta da placebo, a cikin primary Gacin ƙarshe na Abubuwan da modified canzawa Likita ta Global Ƙimar na genitalia (sPGA-G) martani (ayyana a matsayin wani sPGA-G ci na bayyane (0) ko kusan bayyane (1) tare da aƙalla raguwar maki 2 daga tushe) a mako na 16.      

Bugu da kari, an kuma sadu da duk mahimman abubuwan ƙarshen na biyu tare da ma'ana da ingantaccen haɓakawa a cikin Matsalolin Matsakaicin Mahimmanci na Jiki (GPI-NRS) amsa (wanda aka ayyana azaman aƙalla raguwar maki 4 daga tushe a cikin ƙimar abu na GPI-NRS a cikin Alamomin Psoriasis na Genital Psoriasis. ga batutuwa masu ƙima na asali na ≥ 4); canjin yanayin yanayin jiki (BSA) ya canza daga asali; Ƙididdigar Ƙwararrun Rayuwa (DLQI) ta canza daga asali; da amsawar Kima ta Duniya na Likita (sPGA) (wanda aka ayyana azaman ƙimar sPGA na fili (0) ko kusan bayyana (1) tare da aƙalla raguwar maki 2 daga tushe) a mako na 16 tare da Otezla tare da placebo.

Nau'in da adadin abubuwan da suka faru mara kyau da aka lura a cikin wannan gwaji sun yi daidai da sanannen bayanin martaba na Otezla. Abubuwan da aka fi sani da mummunan al'amuran da suka faru a cikin akalla 5% na marasa lafiya a cikin kowane rukunin jiyya sune gudawa, ciwon kai, tashin zuciya da nasopharyngitis.

Marasa lafiya da suka kammala kashi biyu na makafi na gwaji sun ci gaba ko sun canza zuwa Otezla a lokacin tsawan lokaci na binciken kuma za a bi da su ta hanyar mako 32. Binciken yana gudana kuma an shirya kammalawa a farkon rabin 2022.

Za a ƙaddamar da cikakkun sakamakon binciken na makonni 16 na makafi biyu don gabatarwa a taron likita mai zuwa.

A cikin Amurka, an amince da Otezla don kula da tsofaffi marasa lafiya tare da matsakaici zuwa matsananciyar plaque psoriasis waɗanda ke takarar phototherapy ko tsarin jiyya, manya marasa lafiya tare da cututtukan psoriatic amosanin gabbai da kuma ga manya masu fama da cututtukan baki masu alaƙa da Cutar Behcet. Tun lokacin amincewar FDA ta farko a cikin 2014, Otezla an wajabta shi ga marasa lafiya sama da 650,000 a duk duniya tare da matsakaici-zuwa-m plaque psoriasis, cututtukan psoriatic mai aiki ko Cutar Behcet.

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Linda Hohnholz, editan eTN

Linda Hohnholz tana rubuce-rubuce da gyara labarai tun farkon fara aikinta. Ta yi amfani da wannan sha'awar a wurare kamar su Hawaii Pacific University, Chaminade University, da Hawaii's Discovery Center, da yanzu TravelNewsGroup.

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